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• December, 2011 •

Editorial

Dear GynEndocrinologists,
Are you ready for Good Ol’ Santa Claus?

Also this year has come to an end. December is a special month, the month of the annual summary, when one thinks about the year making the sum of victories and defeats in the hopes that the following year will bring more fortune and happiness. But December is also the time to remember what happened in the World. Winds of war and revolution have begun to blow in Tunisia in January, spreading to other countries of North Africa as Egypt as Lybia bringing the disappearance of historical leaders such as Mubarak and al-Qaddafi. The economic downturn has dominated the end of the year. Europe has repeatedly risked default and the long-awaited globalization has made many people poor and few people very rich. What else? Nature did not help, as well. In March a massive earthquake and the following tsunami devastated Japan, killing over 13.000 people and leading to the disaster at the Daiichi nuclear power plant. In parallel, one of the worst U.S. tornado seasons stroked Alabama killing over 1.000 people. Good news? King Abdullah of Saudi Arabia has granted women the right to vote and to run for office in future elections … This is something that we really welcome. Equal rights and duties for both genders. This is something worth being written in our letter to Santa Claus…
In our small community, we are waiting to receive the gift of an exciting ISGE 2012 congress. We are now at the deadline for submission of abstracts and posters for the 2012 World Congress of Gynecological Endocrinology. Hurry up! Don’t miss the chance to be with all those count in this field in Florence! The scientific program has never been as exciting… In addition, with the Society’s contibution to 100 young researchers under 34 years, the Congress will be flooded by young and sharp brains striving to show their cutting edge research. See who they are on the official website of the Congress.
Happy Holiday Season to all the GynEndocrinologists!!

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Dehydroepiandrosterone (DHEA) supplementation increases baseline follicular phase progesterone levels

DGYE-2010-0325.R2 4

Weissman, Ariel (contact); Horowitz, Eran; Ravhon, Amir; Golan, Abraham; Levran, David

Abstract: The use of dehydroepiandrosterone (DHEA) supplementation in infertile patients with diminished ovarian reserve has become increasingly popular. It has been our observation that serum progesterone levels during the follicular phase are often increased during controlled ovarian stimulation when DHEA is co-administered. Our aim was to compare progesterone levels during the follicular phase before and during DHEA supplementation in women with diminished ovarian reserve undergoing IVF. In a case control study, we compared progesterone levels during the follicular phase in IVF cycles before and during DHEA supplementation in 15 women with diminished ovarian reserve who received 75 mg of DHEA daily. Progesterone levels on stimulation day 5 (ng/mL) (0.58±0.29 vs. 1.54 ±0.49; p<0.0001); and on the day of hCG administration (0.75+0.31 vs. 1.87±0.49; p<0.0001) were significantly higher during DHEA treatment. The number of retrieved and fertilized oocytes was similar in both groups. DHEA administration during IVF cycles in women with diminished ovarian reserve causes a significant elevation of progesterone levels without an apparent deleterious effect on cycle outcome

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Oral micronized progesterone combined with vaginal progesterone gel for luteal support

DGYE-2010-0282.R1 4 pag

Tomic, Vlatka (contact); Tomic, Jozo; Zigmundovac Klaic, Djurdja

Abstract: The aim of the present study was to compare the efficacy and satisfaction rate of combined therapy of oral micronized progesterone capsules and vaginal progesterone gel versus monotherapy with vaginal progesterone gel in luteal support.

A case-control study was performed on a total number of 370 women aged <45 years undergoing IVF-ET treatment. The patients received either combination of Crinone 8% vaginal gel, 90mg daily dose, and Utrogestan oral capsules 3 x 100mg, or Crinone 8% vaginal gel, 90mg daily. Progesterone supplementation begun on the day of oocyte retrieval and continued until pregnancy was tested and in the case of pregnancy until week 8.

The comparable rates of ongoing pregnancies were noted with use of combined-progesterone therapy (39.5%) and progesterone-monotherapy (33.5%).

Abortion rate (6.4% vs. 15.6%) was significantly lower with the use of combined therapy. Tolerability and satisfation of both supplements was almost equal but bleeding occurred more frequently in the progesterone-monotherapy group.

In conclusion, the efficacy, satisfaction and tolerability of combined and vaginal progesterone supplements were comparable, but bleeding in early pregnancy and abortion rate presented more frequently with the use of vaginal progesterone.

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Cervical twin ectopic pregnancy after IVF-ET: Case report

DGYE-2010-0242.R2 3

Youssef, Mohamed (contact); Aboulfoutouh, Ismail; Mady, Amir; Zakaria, Ahmed; Khattab, Sherif

Abstract: Introduction: cervical twin ectopic pregnancy after IVF-ET is rare and catastrophic complication. However, here is no consensus on the best treatment strategy. Patient and Method: case report of cervical twin ectopic pregnancy after IVF-ET treated by transvaginal ultrasound guided aspiration plus systemic single injection of methotrexate, which followed by full term delivery in next IVF-ET cycle. Conclusion: transvaginal ultrasound-guided aspiration and systemic methotrexate administration can be safely and easily used to treat cervical ectopic pregnancies and to preserve the fertility of the patient without any major complications

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