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Paraoxonase-1 (PON1) Is Not Affected in Polycystic Ovary Syndrome (PCOS) without Metabolic Syndrome and Insulin Resistance, But Oxidative Stress Is Altered

DGYE-2010-0346.R1 5

Torun, Ayse Nur (contact); Vural, Mehmet; Cece, Hasan; Camuzcuoglu, Hakan; Toy, Harun; Aksoy, Nurten

Abstract: Paraoxonase-1 (PON1) activity is decreased in polycystic ovary syndrome (PCOS) having metabolic syndrome (MetS) or insulin resistance (IR). We aimed to assess PON1 activity and oxidative stress in PCOS without MetS or IR. Metabolic and hormonal parameters, high-sensitive C-reactive protein (hs-CRP), oxidative stress parameters (total antioxidant status (TAS), total oxidative stress (TOS), oxidative stress index (OSI), lipid hydroperoxide (LOOH), total free sulfhydryl (-SH) groups), PON and arylesterase were analysed in 30 normal weighed PCOS patients without MetS or IR and 20 normal controls. Hs-CRP, PON, arylesterase and TAS levels of PCOS and control groups were similar. LOOH, TOS and OSI of PCOS group were higher than in the controls (p<0.05; p<0.001 and p<0.001 respectively). -SH group levels showed a positive correlation with free testosterone (fT). TOS positively correlated with free androgen index (FAI), body mass index (BMI), waist-to-hip ratio (WHR), LOOH, and OSI. This study showed that oxidative stress is increased in PCOS even if the absence of MetS or IR. PON1 activity appears not to be affected in PCOS without MetS and IR. Several metabolic and antropometric risk factors may aggravate this altered oxidative state in PCOS.

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