Blog dedicated to the continuous education in Gynecology and Endocrinology

 

<- Back to home

AGEING AND INFERTILITY: AN OVERVIEW

Castelo-Branco, Camil

AIM: To critically discuss the use of Tibolone (T), in light of a series of very recent double-blind placebo (PL) controlled trials (LISA, LIFT, OPAL, THEBES, LIBERATE) conducted worldwide in a large number of postmenopausal women (PMW). METHODS: The most relevant publications on T therapy in PMW were considered with emphasis on menopausal symptoms, quality of life, sexuality, bone, cardiovascular system (CVS) and oncologic risk. RESULTS: T significantly relieves climacteric symptoms and improves mood and sexual well-being (LISA). T is as effective as EPT in preventing bone loss and reducing the relative risk of vertebral and non-vertebral fractures (LIFT). By using surrogate endpoints of the individual risks for the CVS, studies show mixed results, but a favourable effect on acute miocardial infarction and thromboembolism has been documented (THEBES, LIFT, OPAL). While findings about endometrial and colon cancer are reassuring, conclusive data on breast cancer risk with T are not available and an increased risk of recurrence in women with previous breast cancer emerged (LIBERATE). CONCLUSIONS: T is effective in treating menopausal syndrome with a good tolerability profile. In spite of some unsolved issues in term of safety, T is still a good treatment option for early PMW.

Post to Twitter Post to Facebook

< Back to home page

© International Society of Gynecological Endocrinology - Privacy Policy