Blog dedicated to the continuous education in Gynecology and Endocrinology

 

Effects of intrauterine exposure to synthetic glucocorticoids on fetal, newborn, and infant hypothalamic-pituitary-adrenal axis function in humans: a systematic review.

10) Endocr Rev. 2009 Dec;30(7):753-89.

Tegethoff M, Pryce C, Meinlschmidt G.

BACKGROUND: Synthetic glucocorticoids are commonly used in reproductive medicine. Fetal organ systems are highly sensitive to changes in the intrauterine environment, including overexposure to glucocorticoids. Structural and functional alterations resulting from such changes may persist throughout life and have been associated with diverse diseases. more

Post to Twitter Post to Facebook

Maternal smoking and developmental changes in luteinizing hormone (LH) and the LH receptor in the fetal testis.

3) J Clin Endocrinol Metab. 2009 Dec;94(12):4688-95.

Fowler PA, Bhattacharya S, Gromoll J, Monteiro A, O’Shaughnessy PJ.

CONTEXT: The LH receptor (LHCGR) drives fetal testosterone secretion, which is vital for human masculinization. Maternal smoking is associated with defective masculinization, but the relationship between smoking, tropic hormones, testosterone, and functional LHCGR expression is poorly understood. more

Post to Twitter Post to Facebook

EFFECTS OF INTRAUTERINE EXPOSURE TO SYNTHETIC GLUCOCORTICOIDS ON FETAL, NEWBORN, AND INFANT HYPOTHALAMIC-PITUITARY-ADRENAL AXIS FUNCTION IN HUMANS: A SYSTEMATIC REVIEW

1) Endocr Rev. 2009 Oct 16.

Tegethoff M, Pryce C, Meinlschmidt G.

Background: Synthetic glucocorticoids are commonly used in reproductive medicine. Fetal organ systems are highly sensitive to changes in the intrauterine environment, including overexposure to glucocorticoids. Structural and functional alterations resulting from such changes may persist throughout life and have been associated with diverse diseases. One system that could be particularly sensitive to fetal glucocorticoid overexposure is the hypothalamic-pituitary-adrenal (hpa) axis. Many human studies have investigated this possibility, but a systematic review to identify consistent, emergent findings is lacking. more

Post to Twitter Post to Facebook

MACROSOMIA IN WELL CONTROLLED CSII TREATED TYPE I DIABETIC PREGNANCY

Ohad Cohen,  Naomi Keidar, Michal Simchen, Boaz Weisz, Mordechai  Dolitsky,  Eyal Sivan

Objective: To survey the effect of tight glycemic control by insulin pumps, of pregestational type 1 diabetic women on pregnancy outcome.

Methods: 12 consecutive type 1, insulin pump treated, diabetic patients followed in the high risk maternal –fetal clinic were ascertained. Data regarding glucose control was assessed and correlated with pregnancy outcome. more

Post to Twitter Post to Facebook

COMPARISON OF THE EFFICIENCY OF SECOND-TRIMESTER NASAL BONE HYPOPLASIA AND INCREASED NUCHAL FOLD IN DOWN SYNDROME SCREENING

Odibo AO, Sehdev HM, Gerkowicz S, Stamilio DM, Macones GA.

Am J Obstet Gynecol. 2008 Sep;199(3):281.e1-5.

OBJECTIVE: The purpose of this study was to compare the efficiency of second-trimester nasal bone hypoplasia (NB) and increased nuchal fold (NF) in Down syndrome screening. STUDY DESIGN: This was a prospective multicenter cohort study of women who underwent an anatomic survey between 16 and 22 weeks of gestation. The fetal NB and other markers of fetal aneuploidy that included NF were evaluated. more

Post to Twitter Post to Facebook

© International Society of Gynecological Endocrinology - Privacy Policy