Blog dedicated to the continuous education in Gynecology and Endocrinology

 

Altered urinary profiles of endogenous steroids in postmenopausal women with adenocarcinoma endometrii

Gőcze, Péter; Bufa, Anita; Bíró, Ildikó; Poór, Viktória; Molnár, Gábor; Kovács, Kálmán; Felinger, Attila; Jeges, Sára; Kilár, Ferenc

Abstract: Objective. The potential role of androgen metabolism as co-factors in the development of carcinoma endometrii was investigated. Design. The urinary concentration of 23 androgen, progesterone and corticoid metabolites were quantitatively determined by gas chromatography-mass spectrometry with selected ion-monitoring. We obtained 24-hour urine samples from 13 patients with adenocarcinoma endometrii and from 10 age-matched normal female subjects. In the course of the urinary steroid determination we observed changes in the steroid profiles in the diseas examined compared to the same age and same sex control group. Profiling urinary steroids has to give comprehensive information about the synthesis of steroids including the glandular and peripheral steroid metabolisms. Results. The concentrations of 16-OHD, PD 5-PT were not significantly different in the two groups. The concentrationsDand -CL,a5-PT, THE, THA, THB, aTHB, THF, aTHF, Dof An, Et, 11-OH-An, 11-OH-Et, PT, -C were significantly lower in the postmenopausal women witha-CL, and b adenocarcinoma than in the controls. Conclusion. The changes in the concentrations of single metabolites point out the important role of steroid group, thus providing help in the recognition and treatment of diseased states.

Post to Twitter Post to Facebook

ENDOMETRIAL CANCER, ADVANCES IN MEDICAL AND SURGICAL TREATMENTS

powered by WordPress Multibox Plugin v1.3.5

Hormonal control of endometrial proliferation and differentiation
Di Carlo C.

powered by WordPress Multibox Plugin v1.3.5

Surgical treatment of endometrial cancer: new perspectives
Bolis P.F.

powered by WordPress Multibox Plugin v1.3.5

Medical management and fertility preservation in patients with endometrial cancer
Barri P.

powered by WordPress Multibox Plugin v1.3.5

The treatment of uterine carcinosarcoma
Gadducci A.

Post to Twitter Post to Facebook

The fertility-sparing treatment in patients with endometrial atypical hyperplasia and early endometrial cancer: a debated therapeutic option

Angiolo Gadducci, Nicoletta Spirito, Elena Baroni, Roberta Tana, and Andrea Riccardo Genazzani.

Fertility-sparing treatment may represent a realist option for accurately selected young patients with endometrial atypical hyperplasia or well differentiated, early endometrial cancer. Oral progestins, and especially medroxiprogesterone acetate [MPA] and megestrol acetate with different doses and schedules, represent the most commonly used hormone agents in this clinical setting. more

Post to Twitter Post to Facebook

Interview with J Prat

powered by WordPress Multibox Plugin v1.3.5

Endometrial Cancer
J Prat

Post to Twitter Post to Facebook

Cancer and reproduction

powered by WordPress Multibox Plugin v1.3.5


Case-control study of breast cancer risk for levonorgestrel-releasing intrauterine devices
Voigt Kristina

powered by WordPress Multibox Plugin v1.3.5

The issue of ovarian tissue cryopreservation in children with Hodgkin´s lymphoma
Fabbri Raffaella

powered by WordPress Multibox Plugin v1.3.5

Conservative treatment of microinvasive adenocarcinoma of the cervix
Del Pup Lino

powered by WordPress Multibox Plugin v1.3.5

How to treat vagin-al atrophy and dispareunia in oncological patients?
Del Pup Lino

(13th World Congress on Human Reproduction – March 5-8 2009)

Post to Twitter Post to Facebook

© International Society of Gynecological Endocrinology - Privacy Policy