Blog dedicated to the continuous education in Gynecology and Endocrinology

 

CURRENT DIAGNOSIS AND TREATMENT OF INTERSTITIAL PREGNANCY.

2) Am J Obstet Gynecol. 2010 Jan;202(1):15-29.

Moawad NS, Mahajan ST, Moniz MH, Taylor SE, Hurd WW.

The incidence of interstitial pregnancy is rising. Traditional treatment with laparotomy, hysterectomy, or cornual wedge resection is associated with high morbidity and detrimental effects on future fertility. A diverse array of alternate treatments has been introduced over the last 3 decades, with the common goal of achieving a minimally invasive, standardized management strategy. This has been facilitated by impressive strides towards prompt diagnosis, both radiologically and chemically. In this review, we explore the current state of the art diagnostic criteria and the clinically significant diverse therapeutic options with supporting literature. Finally, we propose a structured, best-practice management plan for the once-lethal interstitial pregnancy, based on the current literature.

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UMBILICAL ARTERY DOPPLER INDICES IN SMALL FOR GESTATIONAL AGE FETUSES: CORRELATION WITH ADVERSE OUTCOMES AND PLACENTAL ABNORMALITIES.

3) J Ultrasound Med. 2009 Dec;28(12):1603-10.

Dicke JM, Huettner P, Yan S, Odibo A, Kraus FT.

OBJECTIVE: The purpose of this study was to compare the screening efficiency of the umbilical artery systolic to diastolic ratio (S/D), pulsatility index (PI), and absent end-diastolic flow (AEDF) for adverse pregnancy outcomes and placental abnormalities in small for gestational age (SGA) fetuses. more

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ENDOMETRIAL CYSTEINE-RICH SECRETORY PROTEIN 3 IS INHIBITED BY HUMAN CHORIONIC GONADOTROPHIN, AND IS INCREASED IN THE DECIDUA OF TUBAL ECTOPIC PREGNANCY.

Mol Hum Reprod. 2009 May;15(5):287-94

Horne AW, Duncan WC, King AE, Burgess S, Lourenco PC, Cornes P, Ghazal P, Williams AR, Udby L, Critchley HO.

Ectopic pregnancy (EP) remains a considerable cause of morbidity and occasional mortality. Currently, there is no reliable test to differentiate ectopic from intrauterine gestation. We have previously used array technology to demonstrate that differences in gene expression in decidualized endometrium from women with ectopic and intrauterine gestations could be used to identify candidate diagnostic biomarkers for EP. more

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CONSERVATIVE MANAGEMENT OF CERVICAL ECTOPIC PREGNANCY.

Fertil Steril. 2009 Mar;91(3):671-4.

Moen V, Brudin L, Rundgren M, Irestedt L.

OBJECTIVE: To evaluate the safety and efficacy of a minimally invasive approach in the management of cervical ectopic pregnancies. DESIGN: Retrospective case series. SETTING: University tertiary care hospital. PATIENT(S): Twenty-four women diagnosed with cervical ectopic pregnancy managed conservatively. INTERVENTION(S): Systemic methotrexate alone or combined with ultrasound-guided fetal intracardiac injection of potassium chloride. more

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COMPARISON OF THE EFFECT OF SINGLE-DOSE AND MULTIPLE-DOSE METHOTREXATE THERAPY ON TUBAL PATENCY.

Fertil Steril. 2007 Nov;88(5):1288-92.

Guven ES, Dilbaz S, Dilbaz B, Ozdemir DS, Akdag D, Haberal A.

OBJECTIVE: To compare tubal patency by using hysterosalpingography (HSG) in women with unruptured ectopic tubal pregnancy who were treated with either single-dose or multiple-dose methotrexate (MTX) regimen.
DESIGN: A case series with a retrospective statistical analysis. SETTING: Maternity and teaching hospital in Turkey. more

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