Blog dedicated to the continuous education in Gynecology and Endocrinology

 

Smoking habit , immune supression, oral contraceptive use, and hormone replacement therapy use and cervical carcinogenesis : a review of the literature

DGYE-2010-0303.R1 8 pag

Gadducci, Angiolo (contact); Barsotti, Cecilia; Cosio, Stefania; Domenici, Lavinia; Genazzani, Andrea

Abstract: High- risk human papillomavirus [HPV]s are involved in the etiopathogenesis of cervical intraepithelial neoplasia [CIN] and cervical cancer. After taking HPV into account, smoking habit appears to be the most significant environmental risk factor, and the risk of this malignancy increases significantly with intensity and duration of smoking. Women with human immunodeficiency virus [HIV] infection, experience a higher incidence of CIN and invasive cervical cancer. Among HIV+ women the highly active antiretroviral therapy increases the regression rate of CIN, but the majority of these lesions do not regress to normal. As far as oral contraceptive [OC]s, a systematic review of 28 studies found that, compared with never pill users, the relative risk [RR] of cervical cancer increased with increasing duration of OC use. The results were similar for squamous cell carcinoma and adenocarcinoma, and the RRs decreased after pill discontinuation. However, by weighing risks and benefits, the World Health Organization does not recommend any change in OC practice. There is no correlation between hormone replacement therapy and cervical cancer. Experimental data have shown that estradiol and progesterone can modulate the host immune response to HPV16. Prophylactic vaccination in conjunction with cervical screening is the best prevention strategy for cervical cancer

Post to Twitter Post to Facebook

COMPARISON OF LIQUID-BASED CYTOLOGY WITH CONVENTIONAL CYTOLOGY FOR DETECTION OF CERVICAL CANCER PRECURSORS: A RANDOMIZED CONTROLLED TRIAL

) JAMA. 2009 Oct 28;302(16):1757-64.

Siebers AG, Klinkhamer PJ, Grefte JM, Massuger LF, Vedder JE, Beijers-Broos A, Bulten J, Arbyn M.

CONTEXT: Liquid-based cytology has been developed as an alternative for conventional cervical cytology. Despite numerous studies and systematic reviews, controversy remains about its diagnostic accuracy.

OBJECTIVE: To assess the performance of liquid-based cytology compared with conventional cytology in terms of detection of histologically confirmed cervical intraepithelial neoplasia (CIN). more

Post to Twitter Post to Facebook

HPV AND CERVICAL CANCER

powered by WordPress Multibox Plugin v1.3.5

HPV vaccination
Borruto F.

powered by WordPress Multibox Plugin v1.3.5

Management of preinvasive lesions of the cervix
Dexeus S.

Post to Twitter Post to Facebook

Cancer and reproduction

powered by WordPress Multibox Plugin v1.3.5


Case-control study of breast cancer risk for levonorgestrel-releasing intrauterine devices
Voigt Kristina

powered by WordPress Multibox Plugin v1.3.5

The issue of ovarian tissue cryopreservation in children with Hodgkin´s lymphoma
Fabbri Raffaella

powered by WordPress Multibox Plugin v1.3.5

Conservative treatment of microinvasive adenocarcinoma of the cervix
Del Pup Lino

powered by WordPress Multibox Plugin v1.3.5

How to treat vagin-al atrophy and dispareunia in oncological patients?
Del Pup Lino

(13th World Congress on Human Reproduction – March 5-8 2009)

Post to Twitter Post to Facebook

LAPAROSCOPIC DEBULKING OF BULKY LYMPH NODES IN WOMEN WITH CERVICAL CANCER: INDICATION AND SURGICAL OUTCOMES.

BJOG. 2009 Apr;116(5):688-92.

Tozzi R, Lavra F, Cassese T, Campanile RG, Pedicini V, Bignardi M, Scorsetti M, Bertuzzi A.

OBJECTIVE: To describe the technique and the surgical outcome of laparoscopic resection of bulky lymph nodes before adjuvant treatment. DESIGN: Prospective pilot study. SETTING: Gynaecological oncology cancer centre. POPULATION: From January 2006 to February 2008, 22 consecutive women presented with cervical cancer and bulky metastatic lymph nodes (>2 cm). more

Post to Twitter Post to Facebook

© International Society of Gynecological Endocrinology - Privacy Policy