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Inhibitory effect of curcumin on uterine leiomyoma cell proliferation

DGYE-2010-0132.R1 [507287] 6 pag

Tsuiji, Kenji; Takeda, Takashi; Li, Bin; Wakabayashi, Atsuko; Kondo, Akiko; Kimura, Tadashi; Yaegashi, Nobuo

Objective: Uterine leiomyomas are the most common gynecological benign tumor and greatly affect reproductive health and wellbeing. They are the predominant indication for hysterectomy in premenopausal women. Curcumin, a well-known component of turmeric, has been reported to prevent various diseases such as cancer, diabetes and obesity. Previous study reported that curcumin represses the proliferation of several tumor cells. However, there has not been a precise characterization of the curcumin-induced inhibition of uterine leiomyoma cells. In this study, we investigated the inhibitory effect of curcumin on leiomyoma cells proliferation. more

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Two cases reports of bowel leiomyomas, and review of literature

Pezzuto, Antonio; Serboli, Giacomo; Ceccaroni, Marcello; Ferrari, Bruno; Nardelli, Giovattistaanni B; Minelli, Luca

We report two cases of two women underwent laparoscopic hysterectomy and myomectomy. During surgery, three myomas were identified as completely detached from the uterus, and attached to the bowel. Patients’s history revealed a laparoscopic myomectomy. Our first hypothesis therefore was that these were lost myomas of the first surgery. However only one leyomyoma was removed in both patients. Therefore, we can assume that these myomas weren’t certainly not lost-myomas and we may conclude that it could be either as residues of previous morcellation or they were pedunculated-myomas that have been spontaneously detached from the uterus and re-implanted onto the bowel.

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Nonsurgical treatments of fibroids: Selective progesterone receptor modulators

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Nonsurgical treatments of fibroids: Selective progesterone receptor modulators Maruo Takeshi

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Genetics of uterine fibroids

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Genetics of uterine fibroidsMorton Cynthia

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Expression of Vascular Endothelial Growth Factor mRNA in Human Leiomyomas

Lewicka DGYE-2009-0156.r1[ID 463724] 5 PAG

Growth factors play a major role in the pathogenesis of uterine myomas. The aim of this study was to evaluate vascular endothelial growth factor (VEGF) mRNA expression during leiomyoma growth at different phases of the menstrual cycle with RT-PCR. We studied 56 patients: 43 with myomas, 13 with healthy myometriums. In patients with myomas (secretory phase), VEGF expression was 2.82 times higher than in control patients (P<0.05). In patients with myomas (phase I), VEGF expression was 2.53 times higher (p<0.05) than in control patients. For all patients with myomas, those that were in menopause had 1.52 times higher VEGF expression than those that menstruated. For patients with healthy myometriums, those that were in menopause had 1.97 times higher VEGF expression than those that menstruated. A comparison of all the patients in menopause revealed that VEGF expression was 2.03-fold higher in those with myomas than in those with healthy myometriums. Conclusions: We observed the highest VEGF mRNA expression in women with myomas that were in menopause. Among menstruating patients, VEGF expression was significantly higher in those with myomas compared to those with a healthy myometrium. This suggested that VEGF may play a significant role in the pathogenesis of uterine myomas.

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