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Metabolomics in serum of ovariectomized rats and those exposed to 17β-estradiol and genistein

Ni, Xin (contact); Zhu, Xiaoyan; Liu, Xinru; He, Ping; Cao, Buqing; lv, Yonghai; Zhang, Weidong – DGYE-2010-0037[487615 ]

Objective Metabolites profiling provides global insights in characterizations and interactions of metabolites under specific physiological or pathologic states.
The aim of this study was to examine serum metabolic changes in bilateral ovariectomized (OVX) rats and those exposed to 17β-estradiol (E2, 30 μg/kg•bw, sc.) or genistein (50 μg/kg•bw, sc.) for 12 weeks. more

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GONADAL DYSFUNCTION AND PELVIC SONOGRAPHIC FINDINGS IN FEMALES WITH THALASSEMIA MAJOR

Karabulut

Abstract: Objective: To investigate pubertal and menstrual problems and evaluate pelvic sonographic findings in patients with ß- thalassemia major. Material and Methods:Twenty-five female patients followed for thalassemia major constituted the study population. Sexual maturation and hormonal status were assessed. Pubertal and menstrual problems were investigated. Results: There was one patient with delayed puberty and five patients with arrested puberty. more

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Effects of bilateral ovariectomy and estrogen replacement therapy on serum leptin, sex hormone binding globulin and insulin like growth factor-I levels

Nar, Asli; Demirtas, Ezgi; Ayhan, Ali; Gurlek, Alper

Abstract: Studies evaluating the effect of estrogen replacement therapy (ERT) on leptin levels are contradictory. The aim of the present study was to investigate effects of bilateral ovariectomy and ERT on serum leptin levels and anthropometric measurements as well as interaction between leptin, SHBG and IGF-I in premenopausal women after bilateral ovariectomy. Twenty-four premenopausal women who undergo bilateral overiectomy were divided into two groups based on whether they received hormonal treatment postoperatively. The studied parameters were evaluated in both groups preoperatively and during the fourth and eighth weeks postoperatively. Serum leptin, testosterone, prolactin, insulin, IGF-1 levels, BMI, HOMA-IR and WHR values did not change in both groups at all times. In the estradiol group, serum SHBG concentrations were significantly higher on weeks 8 compared with control group and basal values (p=0.03 and 0.014, respectively). Leptin levels showed a positive linear correlation with BMI in all groups and at all times evaluated (r=0.80, p<0.01 for controls and r=0.62, p<0.01 for women treated with 17b-estradiol) and with insulin in estradiol group on weeks 4 (r=0.755, p<0.05).

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GEL INFUSION SONOGRAPHY IN THE EVALUATION OF THE UTERINE CAVITY.

2) Ultrasound Obstet Gynecol. 2009 Dec;34(6):711-4.

Van den Bosch T, Betsas G, Van Schoubroeck D, Daemen A, Vandenbroucke V, Cornelis A, De Moor B, Deprest J, Timmerman D.

OBJECTIVES: To compare gel infusion sonohysterography (GIS) with saline contrast sonohysterography (SCSH) with regard to technical feasibility and procedure-related pain experienced by patients. more

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ADVANCES IN HIGH-RISK OBSTETRICS

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Twin pregnancy today
Rizzo N.

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Gynecological and hormonal alterations in adolescents with Metabolic Syndrome (MS)
Rodeiro D.

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Intrauterine growth restriction, new concepts
Valensise H.

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Pathophysiology of pre-eclampsia: new insights
Marozio L.

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