Nar, Asli; Demirtas, Ezgi; Ayhan, Ali; Gurlek, Alper
Abstract: Studies evaluating the effect of estrogen replacement therapy (ERT) on leptin levels are contradictory. The aim of the present study was to investigate effects of bilateral ovariectomy and ERT on serum leptin levels and anthropometric measurements as well as interaction between leptin, SHBG and IGF-I in premenopausal women after bilateral ovariectomy. Twenty-four premenopausal women who undergo bilateral overiectomy were divided into two groups based on whether they received hormonal treatment postoperatively. The studied parameters were evaluated in both groups preoperatively and during the fourth and eighth weeks postoperatively. Serum leptin, testosterone, prolactin, insulin, IGF-1 levels, BMI, HOMA-IR and WHR values did not change in both groups at all times. In the estradiol group, serum SHBG concentrations were significantly higher on weeks 8 compared with control group and basal values (p=0.03 and 0.014, respectively). Leptin levels showed a positive linear correlation with BMI in all groups and at all times evaluated (r=0.80, p<0.01 for controls and r=0.62, p<0.01 for women treated with 17b-estradiol) and with insulin in estradiol group on weeks 4 (r=0.755, p<0.05).