Blog dedicated to the continuous education in Gynecology and Endocrinology

 

REGULATION OF THE ENDOMETRIUM

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Heparin and low molecular weight heparins modulate the decidualization of human endometrial stromal cells
Spratte J

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Endometrial Tuberculosis- Case for Differential Diagnosis in Abnormal Uterine Bleeding In Late Reproductive Period
Singh M

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Molecular mechanisms of SPRMS on endometrial gene expression

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Molecular mechanisms of SPRMS on endometrial gene expression Marbaix Etienne

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Endoemtriotic glandular cells induce MMPs expression in endometrial stromal cells via a NFkB-dependent pathway

Zhao DGYE-2009-0072 [ID 436876] 5 pag

Objective: To explore stroma-epithelium interactions in endometriosis and to identify possible signaling pathways involved in this cross-talk.
Design: Laboratory study via primary cultured endometrial stromal and glandular cells. more

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DIFFERENTIAL ACTIONS OF ESTROGEN AND SERMS IN REGULATION OF THE ACTIN CYTOSKELETON OF ENDOMETRIAL CELLS

4) Mol Hum Reprod. 2009 Oct;15(10):675-85.

Flamini MI, Sanchez AM, Goglia L, Tosi V, Genazzani AR, Simoncini T.

Estrogen and selective estrogen receptor modulators (SERMs) differentially impact endometrial cell function, however, the biological basis of these differences is not established. Deregulated cell adhesion to the extracellular matrix, cell movement and invasion are related to endometrial disorders, such as endometriosis or endometrial cancer. Remodeling of the actin cytoskeleton is required to achieve cell adhesion and movement. more

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EFFECTS OF PROGESTERONE, LEVONORGESTREL AND MEDROXYPROGESTERONE ACETATE ON APOPTOSIS IN HUMAN ENDOMETRIAL ENDOTHELIAL CELLS.

Contraception. 2009 Feb;79(2):139-45. Epub 2008 Oct 9.

Choksuchat C, Zhao S, Deutch TD, Kimble TD, Archer DF.

BACKGROUND: We evaluated apoptosis in human endometrial endothelial cells (HEECs) incubated with progesterone, levonorgestrel (LNG) and medroxyprogesterone acetate (MPA). STUDY DESIGN: HEECs were cultured to near confluence, and the progestogens were added. SETTING: Academic Department of Obstetrics and Gynecology. PATIENTS: No patients were involved. INTERVENTIONS: Progestogens at 5-, 250- and 500-ng/mL concentrations were added to incubations of HEECs for 12, 24 and 48 h. MAIN OUTCOME MEASURE: Apoptosis based on terminal deoxynucleotidyl transferase-mediated deoxy-UTP nick-end labeling (TUNEL), and semiquantification of Bax and Bcl-2. RESULTS: No apoptosis was found by TUNEL, Bax and Bcl-2 after 12 h incubation with any progestogen. TUNEL increased after incubation for 24 and 48 h with progesterone 500 ng/mL; LNG 250, 500 ng/mL and all concentrations of MPA (p<.001), Bax increased and Bcl-2 decreased at all concentrations of MPA and the two highest concentrations of LNG at 48 h (p<.05). CONCLUSION: MPA results in apoptosis of HEECs.

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