Blog dedicated to the continuous education in Gynecology and Endocrinology

 

THE ROLE OF TRANSVAGINAL ULTRASOUND OR ENDOMETRIAL BIOPSY IN THE EVALUATION OF THE MENOPAUSAL ENDOMETRIUM.

2) Am J Obstet Gynecol. 2009 Jul;201(1):5-11.

Goldstein SR.

All postmenopausal women with vaginal bleeding need endometrial assessment. Disposable suction piston biopsy devices have virtually replaced dilatation and curettage despite little scientific validation. In patients with known carcinoma, false-negative rates with such devices range from 2.5-32.4%. Large prospective studies have shown that an endometrial thickness

Post to Twitter Post to Facebook

ENDOMETRIUM PROTECTION AND ACCEPTABILITY OF NASALLY ADMINISTERED CONTINUOUSLY COMBINED HORMONE THERAPY: A MULTICENTRE, MULTINATIONAL, DOUBLE-BLIND TRIAL IN POST-MENOPAUSAL WOMEN EVALUATING THREE REGIMENS OF 17BETA-ESTRADIOL AND NORETHISTERONE WHEN COMPARED WITH AN ORALLY ADMINISTERED 17BETA-ESTRADIOL NORETHISTERONE REGIMEN.

1) Hum Reprod. 2009 Jul;24(7):1739-47.

Rozenberg S, Pornel B, Koninckx PR, Palacios S, Christiansen C.

BACKGROUND: To determine the optimal daily dose of intranasal hormone therapy (HT) in order to achieve adequate endometrial protection. METHODS: Multicentre, double-blind/double-dummy randomized controlled trial (Phase III) was conducted in 1741 women to compare a daily intranasal dose of 350 microg 17beta-estradiol (E2) together with 50, 175 or 550 microg norethisterone (NET) more

Post to Twitter Post to Facebook

BODY MASS INDEX IS A MAJOR DETERMINANT OF ABDOMINAL FAT ACCUMULATION IN PRE-, PERI- AND POST-MENOPAUSAL WOMEN

Carlo Cervellati Ph.D., Francesco Saverio Pansini MD, Ph.D, Gloria Bonaccorsi MD, Giuliana Pascale MD, Bruno Bagni MD, Cristina Castaldini NRs, Stefania Ferrazini, Francesca Ridolfi NRs, Mery Pedriali NRs, Angela Guariento BS, Carlo M. Bergamini MD Ph.D

Objective: To investigate on the role of menopause, Body Mass Index (BMI) and aging on body fat distribution in women. Design: In this population based cross-sectional study 335 women ( 126 in premenopause, 75 in perimenopause and 134 in postmenopause according to STRAW criteria) more

Post to Twitter Post to Facebook

TRANSITIONAL VERSUS SURGICAL MENOPAUSE IN A RODENT MODEL: ETIOLOGY OF OVARIAN HORMONE LOSS IMPACTS MEMORY AND THE ACETYLCHOLINE SYSTEM.

TRANSITIONAL VERSUS SURGICAL MENOPAUSE IN A RODENT MODEL: ETIOLOGY OF OVARIAN HORMONE LOSS IMPACTS MEMORY AND THE ACETYLCHOLINE SYSTEM.

Acosta JI, Mayer L, Talboom JS, Tsang CW, Smith CJ, Enders CK, Bimonte-Nelson HA.

Clinical research suggests that type of ovarian hormone loss at menopause influences cognition. Until recently, ovariectomy (OVX) has been the primary rodent model to examine effects of ovarian hormone loss on cognition. This model limits evaluations to abrupt and complete ovarian hormone loss, modeling less than 12% of women that receive surgical menopause. The majority of women undergo transitional hormone loss via ovarian follicular depletion. 4-vinylcyclohexene-diepoxide (VCD) produces gradual ovarian follicular depletion in the rodent, with hormone profiles more similar to naturally menopausal women versus OVX. We directly compared VCD and OVX models to examine whether type of hormone loss (transitional vs surgical) impacted cognition as assessed on a maze battery, as well as the cholinergic system tested via scopolamine mnemonic challenge and brain AChE activity. Middle-aged rats received either SHAM surgery, OVX surgery, VCD, or VCD then OVX to assess effects of removal of residual ovarian output after transitional menopause and follicular depletion. VCD-induced transitional menopause impaired learning of a spatial recent memory task; surgical removal of residual ovarian hormones by OVX abolished this negative effect of transitional menopause. Further, transitional menopause before OVX was better for memory than an abrupt loss of hormones via Ovx only. Surgical ovarian hormone loss, regardless of menopause history, increased hippocampal AChE activity. Circulating gonadotropin and androstenedione levels were related to cognitive competence. Collectively, findings suggest that in the rat initiation of transitional menopause before surgical ovary removal can benefit mnemonic function, and could obviate some negative cognitive consequences of surgical menopause alone

Post to Twitter Post to Facebook

• May, 2009 •

Metabolic syndrome and cardiovascular risk factors in the menopausal transition

by Prof. Dr. Nestor Siseles,
MD, PhD: Department of Obstetrics and Gynecology,
Medical School, University of Buenos Aires- Argentina
and Prof. Dr. Gabriela Berg, PhD: Lipids and Lipoproteins Laboratory,
School of Pharmacy and Biochemistry. University of Buenos Aires- Argentina

Alterations of the hormonal profile begin in the early 40s, before the complete cessation of menses, consequently changes in risk factors for cardiovascular disease (CVD) such as lipids and anthropometric characteristics could also be observed in this period. It has been necessary to investigate the behavior of these factors during the transition to menopause and still it is not clear when metabolic alterations occur. Some authors have found that perimenopausal women did not show more adverse alterations in lipids than premenopausal ones (1). more

Post to Twitter Post to Facebook

© International Society of Gynecological Endocrinology - Privacy Policy