Blog dedicated to the continuous education in Gynecology and Endocrinology

 

SERUM 25-HYDROXYVITAMIN D IS RELATED TO INDICATORS OF OVERALL PHYSICAL FITNESS IN HEALTHY POSTMENOPAUSAL WOMEN

1) Menopause. 2009 Nov-Dec;16(6):1093-101.

Stewart JW, Alekel DL, Ritland LM, Van Loan M, Gertz E, Genschel U.

OBJECTIVE: Inadequate vitamin D status is related to increased adiposity, risk of falls, and muscle weakness, particularly in older people. We hypothesized that serum 25-hydroxyvitamin D [25(OH)D] is related to physical fitness indices (androidal fat, whole body lean mass, balance, strength) in healthy postmenopausal women.

METHODS: Covariates for fitness indices included age or years since menopause, weight, 25(OH)D, energy expenditure, and calcium intake. Overall and regional (androidal fat mass = waist + hip fat) body composition was assessed (N = 242) via dual-energy x-ray absorptiometry. more

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PRE- VERSUS POSTMENOPAUSAL AGE, ESTRADIOL, AND PEPTIDE-SECRETAGOGUE TYPE DETERMINE PULSATILE GROWTH HORMONE SECRETION IN HEALTHY WOMEN: STUDIES USING SUBMAXIMAL AGONIST DRIVE AND AN ESTROGEN CLAMP

4) J Clin Endocrinol Metab. 2009 Oct 26

Hudson SB, Schroeder DR, Bailey JN, Mielke KL, Erickson D, Miles JM, Bowers CY, Veldhuis JD.

Context: GH-releasing peptide (GHRP), GHRH, and somatostatin are physiological regulators of pulsatile GH secretion.

Hypothesis: Age, independently of abdominal visceral fat (AVF) and basal (nonpulsatile) GH secretion, damps pulsatile GH secretion driven by physiological (rather than pharmacological) amounts of GHRP and GHRH in an experimentally controlled estradiol (E2) milieu. Design and Setting: A prospectively randomized, double-blind parallel-cohort study was conducted at an academic medical center.

Participants: Community-dwelling healthy premenopausal (PRE, age 24 +/- 0.8 yr, n = 20) and postmenopausal (POST, age 63 +/- 1.8 yr, n = 22) women participated in the study. more

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THE ASSOCIATION OF ENDOGENOUS SEX HORMONES, ADIPOSITY, AND INSULIN RESISTANCE WITH INCIDENT DIABETES IN POSTMENOPAUSAL WOMEN

2) J Clin Endocrinol Metab. 2009 Sep 29

Rastogi Kalyani R, Franco M, Dobs AS, Ouyang P, Vaidya D, Bertoni A, Gapstur SM, Hill Golden S.

Context: In postmenopausal women, endogenous bioavailable testosterone (T) and estradiol (E2) have been positively associated, and SHBG has been negatively associated, with incident type 2 diabetes (T2DM). Previous studies have not explored possible factors explaining these relationships. more

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THE HEALTH BENEFITS OF BERRY FLAVONOIDS FOR MENOPAUSAL WOMEN: CARDIOVASCULAR DISEASE, CANCER AND COGNITION

1) Maturitas. 2009 Aug 20;63(4):297-301.

Huntley AL.

There is an increasing amount of research into the health benefits of berry flavonoids. Moreover, the consumption of flavonoid-rich food is on the increase; with women in particular showing a interest in eating a diet which may benefit their long-term health. The aim of this review was to examine the evidence for the benefits of berry flavonoids for cardiovascular health, cancer and cognition in the menopausal woman. Due to the limited amount of clinical data on this subject both in vitro and animal as well as human studies have been included. These data appear to support epidemiological studies that suggest cardiovascular benefits, cancer prevention and cognitive improvement from berry flavonoid consumption. more

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GROWTH HORMONE AND SEX STEROID EFFECTS ON SERUM GLUCOSE, INSULIN, AND LIPID CONCENTRATIONS IN HEALTHY OLDER WOMEN AND MEN

7) J Clin Endocrinol Metab. 2009 Jul 14

Münzer T, Harman SM, Sorkin JD, Blackman MR.

Context: With aging, GH, IGF-I and sex-steroid concentrations and glucose tolerance decrease, and body fat and serum lipids increase. Objective: Assess GH and/or sex steroid administration effects on serum glucose, insulin, insulin sensitivity and lipids in older individuals. Design: Double masked, 2×2 factorial, placebo-controlled, double dummy design Intervention: GH and/or sex steroid (transdermal estradiol plus oral medroxyprogresterone acetate in women=HRT, testosterone enanthate=T in men) administration for six months Participants: Healthy, community dwelling women (n=57) and men (n=74), ages 65-88 y (mean 72 y). Main Outcome Measures: Serum glucose, insulin and insulin sensitivity (QUICKI and ISI) before and during an OGTT, and lipid profiles. Results: In women, GH did not alter OGTT 120 min or 2-hour area under the curve (AUC) glucose values, but increased 120 min insulin and AUC insulin. more

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