Receptor mediated agglutination of human spermatozoa by spermagglutinating factor isolated from Staphylococcus aureus
Objective: We determined the effect of baseline psychological stress and norepinephrine (NE) levels in the follicular fluid on the outcome of in vitro fertilization (IVF). Methods: 107 women with tubal factor infertility were evaluated before and during their first IVF treatment. On the first day of down-regulation, their psychological state was measured using the Zung Self-rating Anxiety (SAS) and Depression Scales (SDS), and defined as baseline psychological stress. more
In spite of the optimization of cryopreservation protocols, post-thawing trauma to mammalian gametes cannot be completely avoided. Based on recent literature, cellular cryodamage in reproductive cells has been extensively characterized in terms of changes in cell structures, whereas biochemical alterations have been poorly more
To evaluate the influence of female age and cause of infertility on the outcome of COH and IUI, we studied 2717 COH cycles in 1035 subfertile couples. The cumulative clinical pregnancy rates were 39% and 58% after three and six COH cycles, respectively. more
Background: In view of the controversies about the skewed X chromosome inactivation (XCI) and premature ovarian failure (POF) association, a meta-analysis of the published data was performed to evaluate the relationship between XCI skewing and POF.
Methods: We searched for all published articles indexed in MEDLINE (1950~2009) and CNKI (1994~2009). Any case-control or cohort study that tested the association between skewed XCI and POF was included and data were extracted independently by two reviewers. We performed this meta-analysis involving 325 cases and 403 controls with Review Manager 4.2 software.
Results: Four eligible studies were selected for meta-analysis. It suggested that there was no significant difference between the incidence of skewed XCI (XCI≥70% skewing) in POF cases comparing to healthy controls, odd ratio (OR) = 1.13 [95% confidence interval (CI): 0.84~1.53, P=0.42]. The link between extremely skewed XCI (XCI≥90% skewing) and POF was also analyzed, and no significant difference was found, either, OR = 1.46 (95% CI: 0.79~2.69, P = 0.22).
Conclusions: Skewed X chromosome inactivation had no association with POF. However, more case-control and cohort studies are needed in the future.