Blog dedicated to the continuous education in Gynecology and Endocrinology


High levels of women’s satisfaction and compliance with transdermal contraception: results from a European multinational, 6 month study


Marelli, Silvia (contact); Jakimiuk, Artur; Crosignani, Piergiorgio; Chernev, Todor; Prilepskaya, Vera; Bergmans, Paul; Von Poncet, Michael; Lee, Emma

OBJECTIVE: To investigate compliance, satisfaction and preference in women using a transdermal contraceptive patch.
METHODS: Women (18–46 years) from 8 European countries used contraceptive patches (norelgestromin 6 mg, ethinylestradiol 600 mcg) for six, 4-week treatment cycles. Compliance, satisfaction, and preference were assessed after 3 and 6 cycles and study completion using self-report methods. more

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Effects of two different low-dose oral contraceptives on plasma homocysteine levels


Odabaşı, Ali Rıza (contact); Küçük, Mert; YUKSEL, Hasan; GUNER, Zekeriya; DEMİRCAN SEZER, SELDA

Objective: The aim of the current study was to investigate the effects of two currently used low-dose combined oral contraceptives (COCs) (20ug ethinyl estradiol [EE] /150ug desogestrel [DSG] versus 20ug EE/ 100ug levonorgestrel [LNG]) on plasma homocysteine levels. Methods: A total of 90 participants were enrolled in the study; 30 of them had not been using COC for at least 12 months prior to their enrollment, while 60 were on regular treatment within 12-18 months. more

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Why does oestrogen-only hormone therapy have such a small impact on breast cancer risk? A Hypothesis.


Eden, John

There seems be irrefutable evidence that oestrogen is involved in the pathogenesis of breast cancer. The disease mostly affects women and the epidemiology of breast cancer relates to reproductive markers such as pregnancy, age at menarche and age of menopause. Most breast cancers elaborate oestrogen receptors (ER) and in such cases endocrine therapies such as tamoxifen and aromatase-inhibitors (AIs) are effective adjuvant treatments. more

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Continuation rates and satisfaction with the Levonorgestrel Intrauterine System. Letter to the Editor in response to an article published in volume 31, by Dr Ewies.

Rybowski, Sarah Inki, Pirjo

Abstract: We respond to the article to provide further information on the issues raised regarding the Levonorgestrel Intrauterine System and provide additional references and data. We believe that the original paper did not represent a systematic and objective analysis of the available data and seek to redress this.

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16 Sumatriptan (50 mg tablets vs 25 mg suppositories) in the acute treatment of menstrually-related migraine and oral contraceptive-induced menstrual migraine: a pilot study

Bellafronte, Manuela, Facchinetti, Fabio; Allais, Gianni; Nappi, R.; Gabellari Castagnoli, Ilaria; Di Renzo, GC; Genazzani, Andrea R; Roncolato, Maurizio; Benedetto, Chiara DGYE-2009-0276

Migraine attacks are common in the perimenstrual period (menstrually-related migraine, MRM) and can be particularly exacerbated by the cyclic suspension of oral contraceptives (oral contraceptive-induced menstrual migraine, OCMM). This cross-over, randomised study evaluated the efficacy and tolerability of rectal (25 mg) and oral (50 mg) sumatriptan in the treatment of 232 menstrual migraine attacks (135 MRM and 97 OCMM). more

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