Blog dedicated to the continuous education in Gynecology and Endocrinology


Chromosomal Abnormalities in women with Premature Ovarian Failure

Papini, Francesca, Artini, Paolo; Ruggiero, Maria; Valentino, Valeria; Uccelli, Alessia; Cela, Vito; Genazzani, Andrea

Premature Ovarian Failure is a complex disorder that results in the early loss of ovarian function; however this disease must be separated from early menopause because these patients can sporadically ovulate and in literature are described pregnancies. The etiology and the patho-physiology of Premature Ovarian Failure are still matter of debate, but is commonly accepted that genetic factors play an important role. This review is aimed to present an overview of known inherited factor implied in the pathogenesis of this disorder to help physician in the counseling of affected pregnant women.

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What is really responsible for bone loss in spontaneous premature ovarian failure? A new enigma.

PEREZ LANA, MARIA (contact); Straminsky, Vanesa; Onetto, Claudia; Martinez, Juliana; Blanco, Georgina; Galluzzo, Liliana; Provenzano, Sergio DGYE-2009-0267[487599]

Objective: To determine if there is a relation between the FSH and estradiol levels with values found in bone mineral density, at lumbar spinal and femoral neck levels, in patients with spontaneous premature ovarian failure as at the time of diagnosis. Method: Cross-sectional study. 85 patients were selected with a diagnosis of premature ovarian failure. Inclusion criteria: 40 women with bone mineral density (BMD) in any of the regions, that is: lumbar spine column or femoral neck. more

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Human menopausal gonadotropin (hMG) versus highly purified-hMG in controlled ovarian hyperstimulation for in vitro fertilization: Does purity improve outcome?

Orvieto, Raoul (contact); Meltcer, Simion; Liberty, Gad; Rabinson, Jacob; Anteby, Eyal; Nahum, Ravit – DGYE-2010-0001[487608]

Objectives: To examine and compare the effect of the two commercially available menotropins (HP-hMG and the traditional hMG) on ovarian stimulation characteristics and IVF cycle outcome. Study Design: We studied 36 patients undergoing at least two controlled ovarian hyperstimulation cycles for IVF, with the same GnRH-analogue protocols, where one included HP-hMG and the other included hMG. more

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• September, 2008 •

Extraembryonic tissues as a source of stem cells

Marcia Riboldi and Carlos Simon


The placenta is a fetal organ, responsible for nutrient and gas exchange between the mother and fetus throughout pregnancy [1]. At day 6.5, gastrulation begins in the posterior region of the embryo. Pluripotent cells located in the epiblast will produce the three germ layers of the embryo and germ cells, as well as the extraembryonic mesoderm of the yolk sac, amnion, and allantois [2,3,4,5]. Eight days after fertilization, the trophoectoderm differentiate into two layers, cytotrophoblast and syncytiotrophoblast. more

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