Blog dedicated to the continuous education in Gynecology and Endocrinology

 

RANDOMISED DOUBLE-BLIND TRIAL OF THE EFFECT OF VITAMIN C ON DYSPAREUNIA AND VAGINAL DISCHARGE IN WOMEN RECEIVING DOXYCYCLINE AND TRIPLE SULFA FOR CHLAMYDIAL CERVICITIS

1) Aust N Z J Obstet Gynaecol. 2009 Oct;49(5):525-30

Khajehei M, Keshavarz T, Tabatabaee HR.

BACKGROUND: Chlamydia trachomatis is the most common bacterial cause of cervicitis. AIM: The aim of this randomised, double-blind trial was to compare the effect of vitamin C on dyspareunia and vaginal discharge in women receiving doxycycline and triple sulfa for chlamydial cervicitis.

METHODS: Eighty women with increased anti-C. trachomatis IgM, reporting abnormal vaginal discharge and dyspareunia, demonstrating signs of cervical oedema and erythema and friability of cervix were included. Thirty-nine women received doxycycline capsules 100 mg twice daily plus triple sulfa vaginal cream once daily for ten days, and 41 received doxycycline capsules 100 mg twice-daily and triple sulfa vaginal cream once daily plus vitamin C tablets 250 mg once daily for ten days. Women were evaluated at follow-up visit, eleventh day, following completion of intervention. more

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Interview with G Creatsas

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Sexual transmitted diseases
G Creatsas

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INFECTIOUS DISEASES AND HUMAN REPRODUCTION

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Male circumcision for HIV prevention: from science to large-scale interventions,
strengthening menĀ“s sexual and reprodcutive health in Africa Schenker Inon

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HPV and human reproduction
Perino Antonio

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Lower genital tract infections
De Santo Davide

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Pelvic infections and fertility
Ness Roberta B.

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Genital tubercolosis and fertility
Malik Sonia

(13th World Congress on Human Reproduction – March 5-8 2009)

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ITRACONAZOLE VS FLUCONAZOLE FOR THE TREATMENT OF UNCOMPLICATED ACUTE VAGINAL AND VULVOVAGINAL CANDIDIASIS IN NONPREGNANT WOMEN: A METAANALYSIS OF RANDOMIZED CONTROLLED TRIALS.

Am J Obstet Gynecol. 2008 Feb;198(2):153-60.
Pitsouni E, Iavazzo C, Falagas ME.

In this metaanalysis of randomized controlled trials (RCTs) we aimed to compare the in vivo and in vitro activity and the safety of per os itraconazole and fluconazole treatment of uncomplicated acute vaginal/vulvovaginal candidiasis in nonpregnant women. We used PubMed, Scopus, Web of Science, and Cochrane Library to identify the studies that were relevant to our metaanalysis RCTs. Six RCTs were included in this study that comprised 1092 enrolled patients with signs and symptoms of vaginal/vulvovaginal candidiasis that was confirmed by microscopy and/or microbiologic cultures that were obtained from the ectocervix and/or vaginal fundus. Overall, there was no difference between itraconazole and fluconazole regarding clinical cure and improvement at the first and second scheduled visit assessments (pooled odds ratio [OR], 0.94 [95% CI, 0.6-1.48] and 1.09 [95% CI, 0.68-1.75], respectively), mycologic cure at the first and second scheduled visit assessments (OR, 0.73 [95% CI, 0.31-1.7] and 0.71 [95% CI, 0.49-1.03], respectively), withdrawal of patients because of severe adverse events (OR, 0.72 [95% CI, 0.16-3.32]), and adverse events noted from the nervous and digestive systems (OR, 1.07 [95% CI, 0.42-2.73] and 1.84 [95% CI, 0.3-11.27], respectively). In conclusion, effectiveness and safety of oral itraconazole and fluconazole in the treatment of acute uncomplicated vaginal/vulvovaginal candidiasis are similar..

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GENITAL HERPES

Lancet. 2008 Dec 22;370(9605):2127-37.
Gupta R, Warren T, Wald A.

Genital herpes is the main cause of genital ulcers worldwide; the prevalence of herpes simplex virus (HSV) type 2 infections in the general population ranges from 10% to 60%. Most genital herpes is caused by HSV-2, although HSV-1 accounts for about half of new cases in developed countries. The risk of HIV acquisition is three times higher in people with HSV-2. Neonatal herpes is an uncommon but serious complication of genital herpes. more

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