Functional role of peroxisome proliferator-activated receptors gamma in glucidic metabolism in of granulosa cells from normal and polycystic ovary syndrome women
Abstract: Objective: The Estradiol-to-Testosterone (E2/T) ratio has been investigated in different diseases but few in vivo data are available with regard to its role in women with PCOS.
The aim of this study was to evaluate the role of the E2/T ratio in the ovulatory function and metabolic pattern in such women.
Methods: We retrospectively evaluated hyperandrogenemia, clinical hyperandrogenism, ovarian morphology, hypothalamo-hypophyseal axis and metabolic syndrome parameters in a cohort of 202 consecutive women affected by PCOS. An oral glucose tolerance test measured areas under the curve for insulin (AUC2hIRI), for glucose (AUC2hglucose), and the HOMA-IR and Matsuda index of insulin resistance were evaluated. Serum progesterone (Pg) was determined from day 20 to day 24 of the menstrual cycle and chronic oligo-anovulation was established if two consecutive cycles were anovulatory.
Results: PCOS-women with normal ovulation [66/202 (32.7%)] showed a significantly higher E2/T ratio than PCOS-women with chronic oligo/anovulation [136/202 (67.3%)] (p<0.05). Using a series of multiple linear regression models, we also investigated which variables correlated with the E2/T ratio. The analysis showed a strongly positive correlation of the E2/T ratio with Pg (β=0.473, p<0.001) and a negative correlation with total cholesterol (β=-0.433, p<0.001).
Conclusions: Our data suggest that in women with PCOS a low E2/T ratio is not only associated with chronic oligo-anovulation, but is also a determinant factor of the atherogenic lipid profile.
Abstract: Objective: To assess the impact of metformin and of two different oral contraceptives containing Cyproterone acetate and Drospirenone, on serum AMH levels, in a cohort of PCOS women with hyperandrogenism.
Design: Prospective randomized study.
Setting: Division of Endocrinology and Human Reproduction, Aristotle University of Thessaloniki
Patients: Forty five (45) women with PCOS diagnosed according to the criteria proposed in 1990 by the NIH.
Interventions: Women with PCOS were randomized into three groups all treated for 6 months: Group A received an OC containing 35mg ethinylestradiol plus 2mg Cyproterone acetate, Group B received an OC containing 30mg ethinylestradiol plus 3mg Drospirenone, and Group C received Metformin 2 x 850mg.
Main outcome measure(s): Anti-Mϋllerian hormone levels were measured by a specific ELISA.
Results: AMH was significantly decreased under treatment with 35mg ethinylestradiol plus 2mg Cyproterone acetate (p=0.002 at 3 months and p<0.001 at 6 months,). Treatment with 30mg ethinylestradiol plus 3mg Drospirenone, and treatment with Metformin 850mgx2 did not significantly affect serum AMH levels.
AMH was significantly decreased under OCs treatment compared to Metformin 850mgx2 (p=0.005).
Conclusion(s): AMH serum levels were significantly decreased under treatment with 35mg ethinylestradiol plus 2mg Cyproterone acetate, due to decrease in androgens and suppression of gonadotropins.
Our aim was to evaluate C-reactive protein (CRP) and serum vaspin levels in women with polycystic ovary syndrome (PCOS) or polycystic ovaries (PCO).
Design: Twenty four women with PCOS and 23 women with PCO constituted the study groups. The control group comprised 24 healthy women. more
IntroductionPolycystic ovarian syndrome (PCOS) is the most common endocrine disorder in women. These patients share common features like obesity with metabolic syndrome. C-reactive protein (CRP) is a low grade chronic inflammation biomarker that independently predicts high risk patients for cardiovascular diseases (CVD). more