Blog dedicated to the continuous education in Gynecology and Endocrinology


Combined metformin and clomiphene citrate versus highly purified FSH for ovulation induction in clomiphene-resistant PCOS women: A randomized controlled trial


Abu Hashim, Hatem; Wafa, Alaa; El Rakhawy, Mohamed

Aim: To compare the effect of combined metformin- clomiphene citrate (CC) with highly purified urinary FSH (HP-uFSH) for ovulation induction in CC-resistant women with polycystic ovary syndrome (PCOS). Methods: 153 anovulatory women with CC-resistant PCOS were selected in this randomized controlled trial. Patients received combined metformin– CC (n=75, 205 cycles) or HP-uFSH (n=78, 186 cycles) for three cycles. more

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Mancini, Fulvia; Tur, Rosa; Martínez, Francisca; Coroleu, Buenaventura; Rodriguez, Ignacio; Barri, Pedro Nolasco

Aim: This article is a systematic review of the literature to establish if there is an advantage in the use of GnRH antagonists (Ant) compared to the long agonist protocol (Ago) in Polycystic Ovarian Syndrome (PCOS) patients. Material and Methods: The meta-analysis was conducted using the MIX software with Mantel-Haenszel weighting method and the fixed effect model. more

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Baseline psychological stress and ovarian norepinephrine levels negatively affect the outcome of IVF

DGYE-2009-0286.R1 [501871]
Original Paper Li, Shang-Wei, Li, Xiao-Hong; Ma, Yu-Gen; Geng, Li-Hong; Qin, Lang; Hu, Han

Objective: We determined the effect of baseline psychological stress and norepinephrine (NE) levels in the follicular fluid on the outcome of in vitro fertilization (IVF). Methods: 107 women with tubal factor infertility were evaluated before and during their first IVF treatment. more

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Serum and follicular fluid levels of IGF-II, IGF-binding protein-4 and pregnancy-associated plasma protein-A in controlled ovarian hyperstimulation cycle between polycystic ovarian syndrome (PCOS) and non-PCOS women

DGYE-2009-0303.R1 [490608]
Zhong, Gang

Objective to investigate the difference of serum and follicular expression patterns for IGFⅡ, IGFBP4 and PAPP-A in COH cycle between PCOS and non-PCOS women. Methods COH was performed for total 30 sterile women (20 with PCOS and 10 with normal ovarian function). The serum and follicular fluid (FF)from dominant follicles levels of IGFⅡ, IGFBP4 and PAPP-A before COH, day of hCG, and were measured using a ELISA. more

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Effects of alpha and beta recombinant FSH (Gonal-F, Puregon) and progesterone upon human endometrial cell proliferation in-vitro: a preliminary study

DGYE-2009-0274.R1[495426] ,Hsieh, Yao-Yuan

Abstract: Endometrial proliferation or regeneration during menstrual cycle is regulated by sexual hormones. However, the effect of gonadotrophins on the endometrial cell growth remains obscure. Herein we aimed to investigate the effects of r-FSH (Gonal-F, Puregon) and progesterone upon the proliferation of human endometrial cells in-vitro. more

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