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FACTORS RELATED TO INCREASED DAYTIME SLEEPINESS DURING THE MENOPAUSAL TRANSITION AS EVALUATED BY THE EPWORTH SLEEPINESS SCALE.

2) Maturitas. 2009 Nov 26.

Chedraui P, Pérez-López FR, Mendoza M, Leimberg ML, Martínez MA, Vallarino V, Hidalgo L.

BACKGROUND: Sleep disorders and sleep-apnea/hypopnea syndromes are very frequent in women, being misdiagnosed in many cases. The menopause, regardless of age, is associated to poor sleep quality and daytime sleepiness that can lead to impaired quality of life, and reduced productivity and functioning.

OBJECTIVE: To assess daytime sleepiness and related risk factors among middle aged Ecuadorian women using the Epworth Sleepiness Scale (ESS).

METHODS: In this cross-sectional study 149 women aged 40-59 years were assessed for hot flush presence and intensity using the Menopause Rating Scale (MRS) and requested to fill out the ESS and a questionnaire containing personal and partner data.

RESULTS: Mean age of surveyed women was 47.6+/-5.5 years, with 67.8% having less than 12 years of schooling, 33.6% being postmenopausal, and 2.7% on hormone therapy. A 10.1% were current smokers and 20.8% were sedentary. According to the MRS (item 1) 51.7% presented hot flushes, which were graded as severe-very severe in 42.8% of cases. Regarding the partner (n=132), erectile dysfunction was present in 10.6%, premature ejaculation 6.1% and 17.4% abused alcohol. Mean total ESS score was 8+/-4.4 (median 8), with 33.6% considered having some degree of daytime sleepiness (ESS score >/=10). Logistic regression analysis determined that postmenopausal status (OR 6.58, CI 95% [2.51-17.23], p=0.001), sedentarism (OR 3.43, CI 95% [1.14-10.26], p=0.02) and hot flush presence (OR 2.61, CI 95% [1.02-6.65], p=0.04) among women were risk factors for increased daytime sleepiness (ESS total score >/=10) whereas partner faithfulness decreased this risk (OR 0.47, CI 95% [0.24-0.90], p=0.02).

CONCLUSION: Increased daytime sleepiness in this middle aged series was related to female (hormonal status and sedentarism) and partner factors; several which are susceptible of intervention.

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THE HEALTH BENEFITS OF BERRY FLAVONOIDS FOR MENOPAUSAL WOMEN: CARDIOVASCULAR DISEASE, CANCER AND COGNITION

1) Maturitas. 2009 Aug 20;63(4):297-301.

Huntley AL.

There is an increasing amount of research into the health benefits of berry flavonoids. Moreover, the consumption of flavonoid-rich food is on the increase; with women in particular showing a interest in eating a diet which may benefit their long-term health. The aim of this review was to examine the evidence for the benefits of berry flavonoids for cardiovascular health, cancer and cognition in the menopausal woman. Due to the limited amount of clinical data on this subject both in vitro and animal as well as human studies have been included. These data appear to support epidemiological studies that suggest cardiovascular benefits, cancer prevention and cognitive improvement from berry flavonoid consumption. more

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CIMICIFUGA RACEMOSA TREATMENT AND HEALTH RELATED QUALITY OF LIFE IN POSTMENOPAUSAL SPANISH WOMEN

Pérez-Lopez Faustino, Juliá Mollá María, García-Sánchez Yolanda, Romeu Albert

Objective: The effects of an isopropanolic aqueous extract of Cimicifuga racemosa (iCR) were evaluated in symptomatic postmenopausal women using the Cervantes health-related quality of life (HR-QoL) scale.
Design: This is a prospective observational study that included 122 symptomatic postmenopausal Spanish women aged between 45 and 59 years. Three groups were formed according to age intervals. Each patient completed the Cervantes HR-QoL scale before and after CR treatment (20 mg, twice a day for 3 months). Changes in global quality of life score and in Cervantes scale HR-QoL domains (menopause and health, psychic, sexuality, and couple relationship) were analysed. more

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THE EFFECT OF TRIFOLIUM PRATENSE DERIVED ISOFLAVONES OVER THE LIPID PROFILE OF POSTMENOPAUSAL WOMEN WITH INCREASED BODY MASS INDEX


PETER CHEDRAUI, GLENDA SAN MIGUEL, LUIS HIDALGO, NANCY MOROCHO  &  SUSANA ROSS

Background. Since current clinical evidence indicates that conventional estrogenic hormone therapy (HT) increases cardiovascular risk,  alternatives to estrogens  are growing in popularity, especially among  high risk populations.  Objective. Determine the effect of Trifolium pratense derived isoflavone supplementation  over the lipid profile of postmenopausal women with increased body mass index (BMI). more

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A SELECT COMBINATION OF CLINICALLY RELEVANT PHYTOESTROGENS ENHANCES ESTROGEN RECEPTOR {BETA}-BINDING SELECTIVITY AND NEUROPROTECTIVE ACTIVITIES IN VITRO AND IN VIVO.

Zhao L, Mao Z, Brinton RD.

Endocrinology. 2008 Sep 25.

We have previously shown that a number of naturally occurring phytoestrogens and derivatives were effective to induce some measures of neuroprotective responses but at a much lower magnitude than those induced by the female gonadal estrogen 17beta-estradiol (17beta-E2). In the present study, we sought to investigate whether a combination of select phytoestrogens could enhance neural responses without affecting the reproductive system. more

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