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Serum vitamin B12 and homocysteine levels in pregnant women with neural tube defect

Ceyhan – DGYE-2009-0164.r1 [ID 463727]

Abstract: Objective: Aim of the study is to investigate the importance of serum vitamin B12 levels in pregnants with fetal neural tube defect.
Study Design: This study consists of 31 pregnant women having fetuses with neural tube defect. more

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INSULIN MODULATES FOOD-RELATED ACTIVITY IN THE CENTRAL NERVOUS SYSTEM

1) J Clin Endocrinol Metab. 2009 Dec 8.

Guthoff M, Grichisch Y, Canova C, Tschritter O, Veit R, Hallschmid M, Häring HU, Preissl H, Hennige AM, Fritsche A.

Context: Previous data suggest a key role of central nervous insulin action in regulating energy homeostasis. Objective: We therefore investigated whether insulin modulates brain responses to food and nonfood pictures in a functional magnetic resonance imaging study.

Design and Patients: Nine healthy, normal-weight subjects underwent two functional magnetic resonance imaging measurements to compare the effects of insulin and placebo administration during a visual recognition task with food and nonfood pictures. Insulin was administered intranasally to raise insulin concentrations in the cerebrospinal fluid without altering systemic effects in the periphery. Metabolic parameters were continuously determined during the experiments.

Main Outcome Measure: We measured the changes in brain activity after intranasal insulin administration. Results: Food pictures were detected faster when compared to nonfood pictures in all conditions without any effect of placebo or insulin. After insulin application, functional magnetic resonance imaging measurements showed a significantly reduced activity in the presence of food pictures compared to placebo in the right and left fusiform gyrus, the right hippocampus, the right temporal superior cortex, and the right frontal middle cortex. The brain activation induced by nonfood pictures remained unaffected by insulin.

Conclusion: We demonstrate that intranasal insulin led to a reduction of activity in brain areas related to object processing and memory and may have an effect on brain activation with regard to the processing of food pictures. This effect might be part of a mechanism that terminates food intake in the postprandial state.

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DHEA SULFATE LEVELS ARE ASSOCIATED WITH MORE FAVORABLE COGNITIVE FUNCTION IN WOMEN.

J Clin Endocrinol Metab. 2007 Dec 11

Davis SR, Shah SM, McKenzie DP, Kulkarni J, Davison SL, Bell RJ.

Context: It has been proposed that dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS) exert neuroprotective effects in the brain, yet evidence of associations between the endogenous levels of these steroids and measures of cognitive function are lacking. Objective: To investigate whether circulating levels of DHEAS independently contribute to aspects of cognitive function in women in the community. more

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FLUTAMIDE AND CYPROTERONE ACETATE EXERT AGONIST EFFECTS: INDUCTION OF ANDROGEN RECEPTOR-DEPENDENT NEUROPROTECTION.

4) Endocrinology. 2007 Jun;148(6):2936-43.
Nguyen TV, Yao M, Pike CJ.

Androgens can exert profound effects on the organization, development, and function of the nervous system through activation of androgen receptors (ARs). Nonsteroidal and steroidal antiandrogens antagonize AR-mediated, classic genomic actions of androgens. However, emerging studies in nonneuronal cells indicate that antiandrogens can act as partial agonists for the AR. more

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REGULATION OF PITUITARY CELL FUNCTION BY ADIPONECTIN

3) Endocrinology. 2006 Oct 12
Rodriguez-Pacheco F, Martinez-Fuentes AJ, Tovar S, Pinilla L, Tena-Sempere M, Dieguez C, Castano JP, Malagon MM

Adiponectin is a member of the family of adipose tissue-related hormones known as adipokines, which exerts anti-diabetic, anti-atherogenic, anti-inflammatory and anti-angiogenic properties. Adiponectin actions are primarily mediated through binding to two receptors expressed in several tissues, AdipoR1 and AdipoR2. Likewise, adiponectin expression has been detected in adipocytes as well as in a variety of extra-adipose tissues, including the chicken pituitary. more

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