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Metabolic and hormonal parameters in postmenopausal women ten years after transdermal estradiol treatment, alone or combined to micronized oral progesterone

DGYE-2010-0019.R1

Pérez-López, Faustino; Cuadros-López, José; Fernández-Alonso, Ana; Chedraui, Peter; Sabatel-López, Rosa; Cuadros-Celorrio, Angela

Background. In a post-WHI era few postmenopausal women complete long term hormonal treatment (HT). Objective. To analyze metabolic/hormonal parameters and frequency of the metabolic syndrome (METS) in postmenopausal women after 10 years of HT. Methods. Retrospective data from parallel cohorts of postmenopausal women receiving HT for 10 years was analyzed. more

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A Novel Regimen of Combination Transdermal Estrogen and Intermittent Vaginally Administered Progesterone for Relief of Menopausal Symptoms

Kroft, Jamie; Klostermann, Natalie; Moody, Joel; Taerk, Evan; Wolfman, Wendy

Objectives: To determine the safety and efficacy of a novel regimen of transdermal estrogen and vaginally administered progesterone for treatment of menopausal symptoms. Study Methods: A retrospective chart review was conducted of menopausal patients aged 46-65, using an estradiol patch and vaginally administered prometrium for at least one year. more

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OESTROGEN PLUS PROGESTIN AND LUNG CANCER IN POSTMENOPAUSAL WOMEN (WOMEN’S HEALTH INITIATIVE TRIAL): A POST-HOC ANALYSIS OF A RANDOMISED CONTROLLED TRIAL

2) Lancet. 2009 Oct 10;374(9697):1243-51.

Chlebowski RT, Schwartz AG, Wakelee H, Anderson GL, Stefanick ML, Manson JE, Rodabough RJ, Chien JW, Wactawski-Wende J, Gass M, Kotchen JM, Johnson KC, O’Sullivan MJ, Ockene JK, Chen C, Hubbell FA; Women’s Health Initiative Investigators.

BACKGROUND: In the post-intervention period of the Women’s Health Initiative (WHI) trial, women assigned to treatment with oestrogen plus progestin had a higher risk of cancer than did those assigned to placebo. Results also suggested that the combined hormone therapy might increase mortality from lung cancer. To assess whether such an association exists, we undertook a post-hoc analysis of lung cancers diagnosed in the trial over the entire follow-up period. more

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Oral stomatitis induced by endogenous progesterone: case report.

E M Minicucci, A B Carrenho, S A T Weber , F M Bombini, R A M A Ribeiro, M E A Marques , D A Ribeiro

Oral stomatitis induced by endogenous progesterone is a rare clinical condition which may be associated with cutaneous involvement. That is probably due to the peak of progesterone production during the luteal phase of the menstrual cycle. In the present case report, a 21-year-old patient displayed recurrent ulcerative lesions located on the buccal mucosa or the upper lip, on a monthly basis since the age of fifteen. Such lesions would always manifest themselves on the second day until the end of the menstrual cycle.

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