Blog dedicated to the continuous education in Gynecology and Endocrinology

 

DHEA IN ELDERLY WOMEN AND DHEA OR TESTOSTERONE IN ELDERLY MEN

2) N Engl J Med. 2006 Oct 19;355(16):1647-59
Nair KS, Rizza RA, O’Brien P, Dhatariya K, Short KR, Nehra A, Vittone JL, Klee GG, Basu A, Basu R, Cobelli C, Toffolo G, Dalla Man C, Tindall DJ, Melton LJ 3rd, Smith GE, Khosla S, Jensen MD

BACKGROUND: Dehydroepiandrosterone (DHEA) and testosterone are widely promoted as antiaging supplements, but the long-term benefits, as compared with potential harm, are unknown. METHODS: We performed a 2-year, placebo-controlled, randomized, double-blind study involving 87 elderly men with low levels of the sulfated form of DHEA and bioavailable testosterone and 57 elderly women with low levels of sulfated DHEA. more

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REGULATION OF PITUITARY CELL FUNCTION BY ADIPONECTIN

3) Endocrinology. 2006 Oct 12
Rodriguez-Pacheco F, Martinez-Fuentes AJ, Tovar S, Pinilla L, Tena-Sempere M, Dieguez C, Castano JP, Malagon MM

Adiponectin is a member of the family of adipose tissue-related hormones known as adipokines, which exerts anti-diabetic, anti-atherogenic, anti-inflammatory and anti-angiogenic properties. Adiponectin actions are primarily mediated through binding to two receptors expressed in several tissues, AdipoR1 and AdipoR2. Likewise, adiponectin expression has been detected in adipocytes as well as in a variety of extra-adipose tissues, including the chicken pituitary. more

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ANDROGEN THERAPY IN WOMEN: AN ENDOCRINE SOCIETY CLINICAL PRACTICE GUIDELINE

2) J Clin Endocrinol Metab. 2006 Oct;91(10):3697-710
Wierman ME, Basson R, Davis SR, Khosla S, Miller KK, Rosner W, Santoro N.

OBJECTIVE: The objective was to provide guidelines for the therapeutic use of androgens in women. PARTICIPANTS: The Task Force was composed of a chair, selected by the Clinical Guidelines Subcommittee (CGS) of The Endocrine Society, six additional experts, a methodologist, and a medical writer. The Task Force received no corporate funding or remuneration. more

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LONG TERM LOW-DOSE ORAL DHEA ADMINISTRATION MODULATES ADRENAL RESPONSE TO ACTH IN EARLY AND LATE POSTMENOPAUSAL WOMEN

Genazzani AR, Pluchino N, Begliuomini S, Stomati M, Bernardi F, Pieri M, Casarosa E, Palumbo M, Genazzani AD and Luisi M

Objective: The aging process is associated with a decline in circulating D5-androgens dehydroepiandrosterone (DHEA) and its sulphate ester, dehydroepiandrosterone sulphate (DHEA-S). Design: To evaluate the effects of a long term (12 months) oral DHEA administration (25 mg/day) on adrenal function, before and after 3, 6 and 12 months of treatment. more

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SHORT-TERM EFFECTS OF AN ASSOCIATION OF ISOFLAVONES, LIGNANS AND CIMICIFUGA RACEMOSA ON CLIMACTERIC-RELATED SYMPTOMS IN POSTMENOPAUSAL WOMEN

Annalidia Sammartino, Virginia Gargano, Costantino Di Carlo, Giovanni Antonio Tommaselli, Wanda Attianese and Carmine Nappi

The aim of this study was to evaluate short-term effects of an association of isoflavones, lignans and cimicifuga racemosa on acute climacteric-related symptoms in postmenopausal women in a double – blind, randomized, placebo – controlled trial performed at the Menopause Clinic of our Department.
Eighty healthy postmenopausal women were randomly assigned to two treatment groups receiving the association (group A n =40) or calcium supplements (group B n =40) for three cycles of 28 days Climacteric-related symptoms were evaluated by Kupperman Index (KI) at baseline and after the 3 cycles of treatment. more

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