RU486 (Mifepristone) new antiprogestins and novel uses
1) Hum Reprod. 2009 Aug;24(8):1862-9.
BACKGROUND: Misoprostol is widely used in obstetrics and gynaecology for medical abortion, cervical priming and induction of labour. To aid the design of effective and safe regimens, we have investigated the pharmacokinetic parameters after the vaginal or sublingual administration of repeated doses of 400 microg of misoprostol. more
Fertil Steril. 2009 May;91(5):1877-80.
OBJECTIVE: To determine the efficacy of a nonsteroidal anti-inflammatory drug vs. paracetamol in pain relief during medical abortion and to evaluate whether nonsteroidal anti-inflammatory drugs interfere with the action of misoprostol. DESIGN: A prospective double-blind controlled study. SETTING: University-affiliated tertiary hospital. more
Contraception. 2009 Feb;79(2):84-90. Epub 2008 Oct 18.
BACKGROUND: A 400 mcg dose of sublingual misoprostol has high efficacy and few side effects when used with 200 mg mifepristone for medical abortion through 63 days’ gestation. STUDY DESIGN: Eligible and consenting women (n=480) were randomized to 400 mcg of misoprostol sublingually or orally, 24 h after 200 mg of mifepristone. Abortion status was assessed two weeks later. more
BJOG. 2008 Oct;115(11):1443-50. Epub 2008 Aug 19
OBJECTIVE: To compare the efficacy and safety of induction of labour by vaginal application of dinoprostone or misoprostol or transcervical insertion of a balloon (Bard) catheter. DESIGN: A non-blinded, randomised, controlled trial. SETTING: A tertiary level Swedish hospital. more