Blog dedicated to the continuous education in Gynecology and Endocrinology

 

17 HYPOXIA-INDUCED APOPTOTIC CELL DEATH IS PREVENTED BY OESTRADIOL VIA OESTROGEN RECEPTORS IN DEVELOPING CNS.

J Neuroendocrinol. 2008 Jan
Pozo Devoto VM, Giusti S, Chavez JC, de Plazas SF.

Neuroprotective effects of oestrogens have been demonstrated against a variety of insults including excitotoxicity, oxidative stress and cerebral ischemia under certain conditions. However, the molecular mechanisms underlying oestrogen neuroprotection are still unclear. We aimed to determine if 17-beta oestradiol (E(2)) administration post-hypoxia (p-hx) was neuroprotective and if these actions were mediated through oestrogen receptors (ER). For this purpose, 12-embyonic day old chickens were subjected to acute hypoxia (8% [O(2)], 60 min), followed by different reoxygenation periods. more

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PROGESTERONE FOR THE TREATMENT OF EXPERIMENTAL BRAIN INJURY; A SYSTEMATIC REVIEW.

Brain. 2008 Feb;131(Pt 2):318-28.
Gibson CL, Gray LJ, Bath PM, Murphy SP.

Steroid sex hormones are potential neuroprotective candidates following CNS injury. All clinical trials to date have examined the effects of oestrogen alone or oestrogen-progestin combination therapy. Experimental studies have suggested that progesterone, in its own right, is a potential neuroprotective agent following acute cerebral injury. more

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DHEA SULFATE LEVELS ARE ASSOCIATED WITH MORE FAVORABLE COGNITIVE FUNCTION IN WOMEN.

J Clin Endocrinol Metab. 2007 Dec 11

Davis SR, Shah SM, McKenzie DP, Kulkarni J, Davison SL, Bell RJ.

Context: It has been proposed that dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS) exert neuroprotective effects in the brain, yet evidence of associations between the endogenous levels of these steroids and measures of cognitive function are lacking. Objective: To investigate whether circulating levels of DHEAS independently contribute to aspects of cognitive function in women in the community. more

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ESTRADIOL-17 -INDUCED HUMAN NEURAL PROGENITOR CELL PROLIFERATION IS MEDIATED BY AN ESTROGEN RECEPTOR -PHOSPHORYLATED EXTRACELLULARLY REGULATED KINASE PATHWAY.

Endocrinology. 2008 Jan;149(1):208-18.

Wang JM, Liu L, Brinton RD. Estradiol-17beta (E(2)) induces rodent hippocampal neural progenitor cell (NPC) proliferation in vitro, in vivo, and after brain injury. The purpose of the present investigation was to determine whether E(2)-induced proliferation observed in rodent model systems generalized to cells of human neural origin and the signaling pathway by which E(2) promotes mitosis of human NPCs (hNPCs). Results of these analyses indicate that E(2) induced a significant increase in hNPC proliferation in a time- and dose-dependent manner. more

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GLUCOCORTICOID PREVENTS BDNF-MEDIATED MATURATION OF SYNAPTIC FUNCTION IN DEVELOPING HIPPOCAMPAL NEURONS THROUGH REDUCTION IN THE ACTIVITY OF MITOGEN-ACTIVATED PROTEIN KINASE.

Mol Endocrinol. 2007 Dec 20 [Epub ahead of print] Links

Kumamaru E, Numakawa T, Adachi N, Yagasaki Y, Izumi A, Niyaz M, Kudo M, Kunugi H.

Increased level of glucocorticoid may be related to the pathophysiology of depressive disorder. The involvement of BDNF (brain-derived neurotrophic factor) in the antidepressive effect has also been suggested, however, the possible influence of glucocorticoid on the action of BDNF in the developing central nervous system (CNS) has not been elucidated. In this study, we investigated the effect of glucocorticoid (Dexamethasone, DEX) on synaptic maturation and function enhanced by BDNF in early developing hippocampal neurons. more

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