Blog dedicated to the continuous education in Gynecology and Endocrinology

 

ESTROGEN RECEPTOR (ER) BETA MODULATES ERALPHA RESPONSES TO ESTROGENS IN THE DEVELOPING RAT VENTROMEDIAL NUCLEUS OF THE HYPOTHALAMUS

Gonzales KL, Tetel MJ, Wagner CK.

Endocrinology. 2008 Sep;149(9):4615-21

The mechanisms by which estradiol exerts specific actions on neural function are unclear. In brain the actions of estrogen receptor (ER) alpha are well documented, whereas the functions of ERbeta are not yet fully elucidated. Here, we report that ERbeta inhibits the activity of ERalpha in an anatomically specific manner within the neonatal (postnatal d 7) brain. more

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NON-CLASSICAL MECHANISMS OF PROGESTERONE ACTION IN THE BRAIN: I. PKC ACTIVATION IN THE HYPOTHALAMUS OF FEMALE RATS.

Balasubramanian B, Portillo W, Reyna A, Chen JZ, Moore AN, Dash PK, Mani SK.

Endocrinology. 2008 Jul 10. [Epub ahead of print] Links

The modulation of gene regulation by progesterone (P) and its classical intracellular regulation by progestin receptors in the brain, resulting in alterations in physiology and behavior has been well studied. The mechanisms mediating the short latency effects of P are less well understood. more

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NON-CLASSICAL MECHANISMS OF PROGESTERONE ACTION IN THE BRAIN: II. ROLE OF CAMK II IN PROGESTERONE-MEDIATED SIGNALING IN THE HYPOTHALAMUS OF FEMALE RATS.

Balasubramanian B, Portillo W, Reyna A, Chen JZ, Moore AN, Dash PK, Mani SK.

Endocrinology. 2008 Jul 10

In addition to the activation of classical progestin receptor (PR)-dependent genomic pathway, progesterone (P) can activate non-classical, membrane-initiated signaling pathways in the brain. more

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PROTEIN PHOSPHATASE 1, PROTEIN PHOSPHATASE 2A, AND CALCINEURIN PLAY A ROLE IN ESTROGEN-MEDIATED NEUROPROTECTION.

Yi KD, Simpkins JW.

Endocrinology. 2008 Jun 19.

It is becoming increasingly clear that protein phosphatases are important modulators of cellular function and that disruption of these proteins are involved in neurodegenerative disease processes. Serine/threonine protein phosphatases such as PP1, PP2A, and calcineurin are involved in hyperphosphorylation of tau as well as beta-amyloid induced cell death. We have previously shown serine/threonine protein phosphatases to be involved in estrogen-mediated neuroprotection. more

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EFFECT OF OESTROGEN RECEPTOR ALPHA AND BETA AGONISTS ON BRAIN NMDA RECEPTORS.

J Neuroendocrinol. 2008 May 28.

Morissette M, Le Saux M, Di Paolo T.

Previous studies have shown the oestradiol modulation of brain NMDA receptors composed of the NR1/2B subunits. The contribution of oestrogen receptor subtypes in this oestradiol modulation of NMDA receptors and its subunits is not known. The following experiments investigated if an oestrogenic receptor subtype is involved in the oestradiol effect on NMDA receptor specific binding and subunit mRNA levels. more

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