Blog dedicated to the continuous education in Gynecology and Endocrinology

 

THE DIFFERENCES IN NEUROPROTECTIVE EFFICACY OF PROGESTERONE AND MEDROXYPROGESTERONE ACETATE CORRELATE WITH THEIR EFFECTS ON BDNF EXPRESSION.

Endocrinology. 2009 Mar 26.

Jodhka PK, Kaur P, Underwood W, Lydon JP, Singh M.

While hormone therapy is used for the treatment of menopausal symptoms, its efficacy in helping reduce the risk of other diseases such as Alzheimer’s disease has been questioned in view of the results of recent clinical trials that appeared inconsistent with numerous basic research studies that supported the beneficial effects of hormones. One possible explanation of this discrepancy may lie in the choice of hormone used. more

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NONCLASSICAL ESTROGEN MODULATION OF PRESYNAPTIC GABA TERMINALS MODULATES CALCIUM DYNAMICS IN GONADOTROPIN-RELEASING HORMONE NEURONS.

2) Endocrinology. 2008 Nov;149(11):5335-44.

Romanò N, Lee K, Abrahám IM, Jasoni CL, Herbison AE.

There is increasing recognition that estrogen exerts multifaceted regulatory effects on GnRH neurons. The acute effects of estrogen on calcium dynamics in these cells were examined using a transgenic mouse line that allows real-time measurement of intracellular calcium concentration ([Ca2+]i) in GnRH neurons in the acute brain slice preparation. 17-beta-Estradiol (E2) at 100 pm-100 nm was found to activate [Ca2+]i transients in approximately 40% of GnRH neurons with an approximate 15-min latency. more

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CLASSICAL ESTROGEN RECEPTOR ALPHA SIGNALING MEDIATES NEGATIVE AND POSITIVE FEEDBACK ON GONADOTROPIN-RELEASING HORMONE NEURON FIRING.

1) Endocrinology. 2008 Nov;149(11):5328-34.

Christian CA, Glidewell-Kenney C, Jameson JL, Moenter SM.

During the female reproductive cycle, the neuroendocrine action of estradiol switches from negative feedback to positive feedback to initiate the preovulatory GnRH and subsequent LH surges. Estrogen receptor-alpha (ERalpha) is required for both estradiol negative and positive feedback regulation of LH. ERalpha may signal through estrogen response elements (EREs) in DNA and/or via ERE-independent pathways. more

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ICI 182,780 PENETRATES BRAIN AND HYPOTHALAMIC TISSUE AND HAS FUNCTIONAL EFFECTS IN THE BRAIN AFTER SYSTEMIC DOSING.

Alfinito PD, Chen X, Atherton J, Cosmi S, Deecher DC.

Endocrinology. 2008 Oct;149(10):5219-26.

Previous reports suggest the antiestrogen ICI 182,780 (ICI) does not cross the blood-brain barrier (BBB). However, this hypothesis has never been directly tested. In the present study, we tested whether ICI crosses the BBB, penetrates into brain and hypothalamic tissues, and affects known neuroendocrine functions in ovariectomized rats. Using HPLC with mass spectrometry, ICI (1.0 mg/kg.d, 3 d) was detected in plasma and brain and hypothalamic tissues for up to 24 h with maximum concentrations of 43.1 ng/ml, and 31.6 and 38.8 ng/g, respectively. more

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A RANDOMIZED, CONTROLLED TRIAL OF MAGNESIUM SULFATE FOR THE PREVENTION OF CEREBRAL PALSY

Rouse DJ, Hirtz DG, Thom E, Varner MW, Spong CY, Mercer BM, Iams JD, Wapner RJ, Sorokin Y, Alexander JM, Harper M, Thorp JM Jr, Ramin SM, Malone FD, Carpenter M, Miodovnik M, Moawad A, O’Sullivan MJ, Peaceman AM, Hankins GD, Langer O, Caritis SN, Roberts JM; Eunice Kennedy Shriver NICHD Maternal-Fetal Medicine Units Network.

Engl J Med. 2008 Aug 28;359(9):895-905.

BACKGROUND: Research suggests that fetal exposure to magnesium sulfate before preterm birth might reduce the risk of cerebral palsy. METHODS: In this multicenter, placebo-controlled, double-blind trial, we randomly assigned women at imminent risk for delivery between 24 and 31 weeks of gestation to receive magnesium sulfate, administered intravenously as a 6-g bolus followed by a constant infusion of 2 g per hour, or matching placebo. more

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