Blog dedicated to the continuous education in Gynecology and Endocrinology

 

GROWTH HORMONE PROMOTES AXON GROWTH IN THE DEVELOPING NERVOUS SYSTEM.

2) Endocrinology. 2009 Jun;150(6):2758-66.

Baudet ML, Rattray D, Martin BT, Harvey S.

Postnatally, endocrine GH is primarily produced by pituitary somatotrophs. GH is, however, also produced in extrapituitary sites, including tissues of the developing nervous system such as the neural retina. more

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ESTROGENS REGULATE POSTTRANSLATIONAL MODIFICATION OF NEURAL CELL ADHESION MOLECULE DURING THE ESTROGEN-INDUCED GONADOTROPIN SURGE

3) Endocrinology. 2009 Jun;150(6):2783-90.

Tan O, Fadiel A, Chang A, Demir N, Jeffrey R, Horvath T, Garcia-Segura LM, Naftolin F.

Estrogen-induced synaptic plasticity (EISP) in the periventricular area (PVA) of the hypothalamus is necessary for the preovulatory gonadotropin surge. Because in situ enzymatic desialization of hypothalamic polysialylated (PSA) neural cell adhesion molecule (NCAM) blocked EISP, more

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RAPID SIGNALING OF ESTROGEN TO WAVE1 AND MOESIN CONTROLS NEURONAL SPINE FORMATION VIA THE ACTIN CYTOSKELETON.

4) Mol Endocrinol. 2009 May 21

Sanchez AM, Flamini MI, Fu XD, Mannella P, Giretti MS, Goglia L, Genazzani AR, Simoncini T.

Estrogens are important regulators of neuronal cell morphology and this is thought to be critical for gender-specific differences in brain function and dysfunction. Dendritic spine formation is dependent on actin remodeling by the WASP-family verprolin homologous (WAVE1) protein, that controls actin polymerization through the actin-related protein 2/3 (Arp2/3) complex. more

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PROGESTOGENS AND BRAIN: AN UPDATE.

Maturitas. 2009 Apr 20;62(4):349-55.

Pluchino N, Cubeddu A, Giannini A, Merlini S, Cela V, Angioni S, Genazzani AR.

Each synthetic progestins has its own specific activities on different tissues, which can vary significantly between progestins of different classes and even within the same class. Indeed, different progestins may support or oppose the effects of estrogen depending on the tissue, thereby supporting the concept that the clinical selection of progestins for HRT is critical in determining potential positive or detrimental effects. more

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PROGESTERONE INCREASES RAT NEURAL PROGENITOR CELL CYCLE GENE EXPRESSION AND PROLIFERATION VIA ERK AND PROGESTERONE RECEPTOR MEMBRANE COMPONENTS (PGRMC) 1 AND 2.

Endocrinology. 2009 Apr 9.

Liu L, Wang J, Zhao L, Nilsen J, McClure K, Wong K, Brinton RD.

Progesterone receptor (PR) expression and regulation of neural progenitor cell (NPC) proliferation was investigated using NPC derived from adult rat brain. RT-PCR revealed that PRA mRNA was not detected in rNPCs, whereas membrane associated PRs, Progesterone Receptor Membrane Components (PGRMC) 1 and 2 mRNA were expressed. more

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