Blog dedicated to the continuous education in Gynecology and Endocrinology

 

SELECTIVE ESTROGEN RECEPTOR MODULATORS DECREASE REACTIVE ASTROGLIOSIS IN THE INJURED BRAIN: EFFECTS OF AGING AND PROLONGED DEPLETION OF OVARIAN HORMONES

2) Endocrinology. 2009 Nov;150(11):5010-5.

Barreto G, Santos-Galindo M, Diz-Chaves Y, Pernía O, Carrero P, Azcoitia I, Garcia-Segura LM.

After brain injury, astrocytes acquire a reactive phenotype characterized by a series of morphological and molecular modifications, including the expression of the cytoskeletal protein vimentin. Previous studies have shown that estradiol down-regulates reactive astrogliosis. In this study we assessed whether raloxifene and tamoxifen, two selective estrogen receptor modulators, have effects similar to estradiol in astrocytes. We also assessed whether aging and the timing of estrogenic therapy after ovariectomy influence the action of the estrogenic compounds. Four groups of animals were studied: 1) young rats, ovariectomized at 2 months of age; 2) middle-aged rats, ovariectomized at 8 months of age; 3) aged rats, ovariectomized at 18 months of age; and 4) aged rats, ovariectomized at 2 months and sham operated at 18 months of age. more

Post to Twitter Post to Facebook

SELECTIVE ESTROGEN RECEPTOR MODULATORS DECREASE REACTIVE ASTROGLIOSIS IN THE INJURED BRAIN: EFFECTS OF AGING AND PROLONGED DEPLETION OF OVARIAN HORMONES

5) Endocrinology. 2009 Sep 24.

Barreto G, Santos-Galindo M, Diz-Chaves Y, Pernía O, Carrero P, Azcoitia I, Garcia-Segura LM.

After brain injury, astrocytes acquire a reactive phenotype characterized by a series of morphological and molecular modifications, including the expression of the cytoskeletal protein vimentin. Previous studies have shown that estradiol down-regulates reactive astrogliosis. In this study we assessed whether raloxifene and tamoxifen, two selective estrogen receptor modulators, have effects similar to estradiol in astrocytes. We also assessed whether aging and the timing of estrogenic therapy after ovariectomy influence the action of the estrogenic compounds. Four groups of animals were studied: 1) young rats, ovariectomized at 2 months of age; 2) middle-aged rats, ovariectomized at 8 months of age; 3) aged rats, ovariectomized at 18 months of age; and 4) aged rats, ovariectomized at 2 months and sham operated at 18 months of age. more

Post to Twitter Post to Facebook

RAPID SIGNALING OF ESTROGEN TO WAVE1 AND MOESIN CONTROLS NEURONAL SPINE FORMATION VIA THE ACTIN CYTOSKELETON

6) Mol Endocrinol. 2009 Aug;23(8):1193-202.

Sanchez AM, Flamini MI, Fu XD, Mannella P, Giretti MS, Goglia L, Genazzani AR, Simoncini T.

Estrogens are important regulators of neuronal cell morphology, and this is thought to be critical for gender-specific differences in brain function and dysfunction. Dendritic spine formation is dependent on actin remodeling by the WASP-family verprolin homologous (WAVE1) protein, which controls actin polymerization through the actin-related protein (Arp)-2/3 complex. more

Post to Twitter Post to Facebook

CSF BIOMARKERS AND INCIPIENT ALZHEIMER DISEASE IN PATIENTS WITH MILD COGNITIVE IMPAIRMENT

8) JAMA. 2009 Jul 22;302(4):385-93.

Mattsson N, Zetterberg H, Hansson O, Andreasen N, Parnetti L, Jonsson M, Herukka SK, van der Flier WM, Blankenstein MA, Ewers M, Rich K, Kaiser E, Verbeek M, Tsolaki M, Mulugeta E, Rosén E, Aarsland D, Visser PJ, Schröder J, Marcusson J, de Leon M, Hampel H, Scheltens P, Pirttilä T, Wallin A, Jönhagen ME, Minthon L, Winblad B, Blennow K.

CONTEXT: Small single-center studies have shown that cerebrospinal fluid (CSF) biomarkers may be useful to identify incipient Alzheimer disease (AD) in patients with mild cognitive impairment (MCI), but large-scale multicenter studies have not been conducted. more

Post to Twitter Post to Facebook

THE DIFFERENCES IN NEUROPROTECTIVE EFFICACY OF PROGESTERONE AND MEDROXYPROGESTERONE ACETATE CORRELATE WITH THEIR EFFECTS ON BRAIN-DERIVED NEUROTROPHIC FACTOR EXPRESSION.

1) Endocrinology. 2009 Jul;150(7):3162-8.

Jodhka PK, Kaur P, Underwood W, Lydon JP, Singh M.

Whereas hormone therapy is used for the treatment of menopausal symptoms, its efficacy in helping reduce the risk of other diseases such as Alzheimer’s disease has been questioned in view of the results of recent clinical trials that appeared inconsistent with numerous basic research studies that supported the beneficial effects of hormones. One possible explanation of this discrepancy may lie in the choice of hormone used. more

Post to Twitter Post to Facebook

© International Society of Gynecological Endocrinology - Privacy Policy