Blog dedicated to the continuous education in Gynecology and Endocrinology

 

BONE MINERAL DENSITY IN ESTROGEN DEFICIENT YOUNG WOMEN.

J Clin Endocrinol Metab. 2009 Apr 28.

Popat VB, Calis KA, Vanderhoof VH, Cizza G, Reynolds JC, Sebring N, Troendle JF, Nelson LM.

Context: Osteoporosis primarily affects postmenopausal women. However, young women with estrogen deficiency also are at increased risk for low bone density. Objective: To assess bone density and associated risk factors for reduced bone density in young, estrogen-deficient women using primary ovarian insufficiency (POI) as the disease model. more

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REGULATION OF BONE MASS, OSTEOCLAST FUNCTION AND OVARIECTOMY-INDUCED BONE LOSS BY THE TYPE 2 CANNABINOID RECEPTOR.

Idris AI, Sophocleous A, Landao-Bassonga E, Van’t Hof RJ, Ralston SH.

Endocrinology. 2008 Jul 17. [Epub ahead of print] Links

The endocannabinoid system has recently been shown to play a role in the regulation of bone metabolism. The type 2 cannabinoid receptor (CNR2) has been reported to regulate bone mass but conflicting results have been reported with regard to its effects on bone resorption and osteoclast function. more

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EFFECTS OF TWO LOW-DOSE COMBINED ORAL CONTRACEPTIVES CONTAINING DROSPIRENONE ON BONE TURNOVER AND BONE MINERAL DENSITY IN YOUNG FERTILE WOMEN: A PROSPECTIVE CONTROLLED RANDOMIZED STUDY.

Gargano V, Massaro M, Morra I, Formisano C, Di Carlo C, Nappi C.

Contraception. 2008 Jul;78(1):10-5. Epub 2008 May 27.

BACKGROUND: The effects of a 21-day combined oral contraceptive containing 30 mcg ethinyl estradiol plus 3 mg drospirenone with a 21-day preparation containing 20 mcg ethinyl estradiol plus 3 mg drospirenone on bone turnover and bone mineral density (BMD) in young fertile women were compared. more

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THE BONE

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Hypogonadism and peak bone mass
Palacios Santiago

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HRT and bone health
Gambacciani Marco

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IMPACT OF LEAN MASS AND FAT MASS ON BONE MINERAL DENSITY: THE HORDALAND HEALTH STUDY.

Maturitas. 2008 Feb 20;59(2):191-200.
Gjesdal CG, Halse JI, Eide GE, Brun JG, Tell GS.

OBJECTIVES: To examine the relationship between soft tissue composition and bone mineral density (BMD) of the hip and whether these relationships differ by gender and age. METHODS: Femoral neck BMD and total body soft tissue composition were measured by dual X-ray absorptiometry in a population-based sample of 5205 men and women 47-50 and 71-75 years old. Analysis of covariance was used to explore possible modifying effects of sex and gender on the impact of fat and lean mass on BMD. more

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