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Altered urinary profiles of endogenous steroids in postmenopausal women with adenocarcinoma endometrii

Gőcze, Péter; Bufa, Anita; Bíró, Ildikó; Poór, Viktória; Molnár, Gábor; Kovács, Kálmán; Felinger, Attila; Jeges, Sára; Kilár, Ferenc

Abstract: Objective. The potential role of androgen metabolism as co-factors in the development of carcinoma endometrii was investigated. Design. The urinary concentration of 23 androgen, progesterone and corticoid metabolites were quantitatively determined by gas chromatography-mass spectrometry with selected ion-monitoring. We obtained 24-hour urine samples from 13 patients with adenocarcinoma endometrii and from 10 age-matched normal female subjects. In the course of the urinary steroid determination we observed changes in the steroid profiles in the diseas examined compared to the same age and same sex control group. Profiling urinary steroids has to give comprehensive information about the synthesis of steroids including the glandular and peripheral steroid metabolisms. Results. The concentrations of 16-OHD, PD 5-PT were not significantly different in the two groups. The concentrationsDand -CL,a5-PT, THE, THA, THB, aTHB, THF, aTHF, Dof An, Et, 11-OH-An, 11-OH-Et, PT, -C were significantly lower in the postmenopausal women witha-CL, and b adenocarcinoma than in the controls. Conclusion. The changes in the concentrations of single metabolites point out the important role of steroid group, thus providing help in the recognition and treatment of diseased states.

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