Blog dedicated to the continuous education in Gynecology and Endocrinology

 

DEVELOPMENT OF LOW-DOSE REPRODUCTIVE HORMONE THERAPIES IN CHINA

Qinsheng Ge, Qinjie Tian, Hung Tseng and Frederick Naftolin

The authors present an historical account of the development of sex hormone treatment from its beginning at the Peking Union Medical College to its present day generalization throughout China. The general theme of this work has been to test low-dose hormone regimens. Notable successes include low-dose oral contraception and menopausal hormone treatment. more

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IS METFORMIN A PRIMARY OVULATORY AGENT IN PCOS PATIENTS?

Kai I. Cheang, Pharm.D., Susmeeta T. Sharma, M.B.B.S., John E. Nestler, M.D.

Insulin resistance is an important pathophysiologic feature of the polycystic ovary syndrome (PCOS).  Insulin resistance and its compensatory hyperinsulinemia contribute to the anovulation, hyperandrogenism, infertility and early pregnancy loss suffered by women with PCOS.  Current evidence supports the role of metformin in the treatment of anovulation in PCOS, both in monotherapy, and concomitantly with clomiphene in clomiphene-resistant patients.  more

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COMPARISON OF FIBRINOLYTIC AND METABOLIC SYSTEM PARAMETERS IN OBESE PATIENTS WITH POLYCYSTIC OVARY SYNDROME AND WOMEN WITH SIMPLE OBESITY

R. Słopień, K. Lewandowski, K. Edyta, K. Zawilska, A. Warenik-Szymankiewicz

The aim of the study was to assess the fibrinolytic and metabolic system parameters in obese patients with PCOS and to compare fibrinolytic and metabolic system parameters in obese PCOS patients and women with simple obesity. We studied 19 obese women with PCOS [mean age: 25,1 +/- 4,6 years, mean body mass index (BMI): 34,7 +/- 3,9 kg/m2] as well as 20 age and BMI-matched ovulatory controls. We measured blood level of 17b-estradiol, testosterone, prolactin, LH, FSH, dehydroepiandrosterone sulfate (DHEAS), total cholesterol, triglycerides, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), glucose and insulin. more

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EFFECTS OF SPORT TRAINING IN ADOLESCENCE ON GROWTH, PUBERTY AND BONE HEALTH

Silvano Bertelloni, Silvia Ruggeri, Giampiero I. Baroncelli

Athletic training in adolescent females is important for their well-being; indeed, it may have both positive or negative effects on some physiological processes, as growth, reproductive axis and bone health.

Adequate physical activity likely exerts neither a positive nor a negative effect on growth. By contrast, intensive training and insufficient diet may have negative influence on growth pattern, probably due to energy deficiency and impairment of growth hormone-IGF-1 axis; net long term-effects of such alterations remain to be established. more

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EFFECT OF LEPTIN ON THE REGULATION OF PLACENTAL HORMONE SECRETION IN CULTURED HUMAN PLACENTAL CELLS

R. Coya, P. Martul, J. Algorta, M. A. Aniel-Quiroga, M.A. Busturia, and R. Señarís

Placenta is an important source of leptin during pregnancy that contributes to the high plasma leptin levels in pregnant women. Leptin and its functional receptors are synthesized in trophoblast cells that, in turn, secrete gestational hormones supporting a paracrine or autocrine role for leptin in the endocrine activity of the placenta. In the present report it has been examined the effect of leptin on in vitro gestational hormones release (human chorionic gonadotropin (hCG), human placental lactogen (hPL), progesterone, oestrogens and testosterone) by human term placental cells in culture. more

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