Blog dedicated to the continuous education in Gynecology and Endocrinology

 

THE CONSENSUS CODING SEQUENCES OF HUMAN BREAST AND COLORECTAL CANCERS

Science. 2006 Oct 13;314(5797):268-74.
Sjoblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE

The elucidation of the human genome sequence has made it possible to identify genetic alterations in cancers in unprecedented detail. To begin a systematic analysis of such alterations, we determined the sequence of well-annotated human protein-coding genes in two common tumor types. Analysis of 13,023 genes in 11 breast and 11 colorectal cancers revealed that individual tumors accumulate an average of approximately 90 mutant genes but that only a subset of these contribute to the neoplastic process. more

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EXERCISE-INDUCED IMPROVEMENT IN VASODILATORY FUNCTION ACCOMPANIES INCREASED INSULIN SENSITIVITY IN OBESITY AND TYPE 2 DIABETES MELLITUS

1) J Clin Endocrinol Metab. 2006 Oct 3
De Filippis E, Cusi K, Ocampo G, Berria R, Buck S, Consoli A, Mandarino LJ

Objective: The present study was undertaken to determine whether improved vasodilatory function accompanies increased insulin sensitivity in overweight, insulin resistant subjects (OW) and type 2 diabetic patients (T2DM) who participated in an 8-week exercise training regimen. Design: Before and after training, subjects had euglycemic clamps to determine insulin sensitivity. more

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PREDICTORS OF URINARY INCONTINENCE IN A PROSPECTIVE COHORT OF POSTMENOPAUSAL WOMEN

3) Obstet Gynecol. 2006 Oct;108(4):855-62
Jackson SL, Scholes D, Boyko EJ, Abraham L, Fihn SD

OBJECTIVE: To prospectively assess risk factors associated with occurrence of urinary incontinence among postmenopausal women. METHODS: We followed up 1,017 postmenopausal health maintenance organization enrollees, aged 55 to 75 years, for 2 years. The primary outcome measures were any urinary incontinence and severe incontinence reported at 12- or 24-month follow-up visits. more

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DHEA IN ELDERLY WOMEN AND DHEA OR TESTOSTERONE IN ELDERLY MEN

2) N Engl J Med. 2006 Oct 19;355(16):1647-59
Nair KS, Rizza RA, O’Brien P, Dhatariya K, Short KR, Nehra A, Vittone JL, Klee GG, Basu A, Basu R, Cobelli C, Toffolo G, Dalla Man C, Tindall DJ, Melton LJ 3rd, Smith GE, Khosla S, Jensen MD

BACKGROUND: Dehydroepiandrosterone (DHEA) and testosterone are widely promoted as antiaging supplements, but the long-term benefits, as compared with potential harm, are unknown. METHODS: We performed a 2-year, placebo-controlled, randomized, double-blind study involving 87 elderly men with low levels of the sulfated form of DHEA and bioavailable testosterone and 57 elderly women with low levels of sulfated DHEA. more

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QUALITY-OF-LIFE IMPACT AND TREATMENT OF URINARY INCONTINENCE IN ETHNICALLY DIVERSE OLDER WOMEN

1) Arch Intern Med. 2006 Oct 9;166(18):2000-6
Huang AJ, Brown JS, Kanaya AM, Creasman JM, Ragins AI, Van Den Eeden SK, Thom DH

OBJECTIVE: To identify the factors associated with greater quality-of-life impact, treatment seeking, and use of treatments for urinary incontinence in ethnically diverse older women. more

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