Blog dedicated to the continuous education in Gynecology and Endocrinology

 

NEOADJUVANT TREATMENT FOR EARLY-STAGE BREAST CANCER: OPPORTUNITIES TO ASSESS TUMOUR RESPONSE

1) Lancet Oncol. 2006 Oct;7(10):869-74
Jones RL, Smith IE.

Primary, preoperative, or neoadjuvant chemotherapy was introduced in the early 1970s as part of an integrated therapeutic approach to treat inoperable locally advanced breast cancer. The approach resulted in high responses, and sufficient downstaging to allow mastectomy in some patients. more

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EFFECT OF RALOXIFENE ON BONE MINERAL DENSITY IN PREMENOPAUSAL WOMEN AT INCREASED RISK OF BREAST CANCER

2) J Clin Endocrinol Metab. 2006 Oct;91(10):3941-6
Eng-Wong J, Reynolds JC, Venzon D, Liewehr D, Gantz S, Danforth D, Liu ET, Chow C, Zujewski J.

CONTEXT: Raloxifene is a promising breast cancer prevention agent in postmenopausal women at increased risk for breast cancer. The effects of raloxifene in premenopausal women are unknown. OBJECTIVE: We evaluated the effect of raloxifene in premenopausal women at increased risk for breast cancer on bone mineral density (BMD). DESIGN: This was a phase II clinical trial. SETTING: This study was conducted at an academic medical center. more

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SURVIVAL PATTERNS AFTER OOPHORECTOMY IN PREMENOPAUSAL WOMEN: A POPULATION-BASED COHORT STUDY

1) Lancet Oncol. 2006 Oct;7(10):821-8
Rocca WA, Grossardt BR, de Andrade M, Malkasian GD, Melton LJ 3rd.

BACKGROUND: A statistical model of death due to ovarian cancer, breast cancer, coronary heart disease, hip fracture, and stroke has suggested that women who undergo prophylactic bilateral oophorectomy are at increased risk of death for all causes. We aimed to investigate survival patterns in a population-based sample of women who had received an oophorectomy and compare these with women who had not received an oophorectomy. more

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AMNIOTIC-FLUID EMBOLISM AND MEDICAL INDUCTION OF LABOUR: A RETROSPECTIVE, POPULATION-BASED COHORT STUDY

4) Lancet. 2006 Oct 21;368(9545):1444-8
Kramer MS, Rouleau J, Baskett TF, Joseph KS; Maternal Health Study Group of the Canadian Perinatal Surveillance System.

BACKGROUND: Amniotic-fluid embolism is a rare, but serious and often fatal maternal complication of delivery, of which the cause is unknown. We undertook an epidemiological study to investigate the association between amniotic-fluid embolism and medical induction of labour. METHODS: We used a population-based cohort of 3 million hospital deliveries in Canada between 1991 and 2002 to assess the associations between overall and fatal rates of amniotic-fluid embolism and medical and surgical induction, maternal age, fetal presentation, mode of delivery, and pregnancy and labour complications. more

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REDUCED LUNG FUNCTION AT BIRTH AND THE RISK OF ASTHMA AT 10 YEARS OF AGE

3) N Engl J Med. 2006 Oct 19;355(16):1682-9
Haland G, Carlsen KC, Sandvik L, Devulapalli CS, Munthe-Kaas MC, Pettersen M, Carlsen KH; ORAACLE.

BACKGROUND: Reduced lung function in early infancy has been associated with later obstructive airway diseases. We assessed whether reduced lung function shortly after birth predicts asthma 10 years later. more

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