DGYE-2010-0364.R1 4 pag
Pérez-López, Faustino (contact); Fernández-Alonso, Ana; Valdera-Simbrón, Carlos; Fiol-Ruiz, Gabriel; Rodríguez-Sánchez, Firma; Chedraui, Peter
Abstract: Background. Vitamin D has been implicated in embryo/placental development and growth; however information in this regard is limited or unavailable.
Objective. To assess 25-hydroxyvitamin D [25(OH)D], free ß-human chorionic gonadotropin (ß-hCG) and pregnancy associated plasma protein A (PAPP-A) status during pregnancy.
Methods. Serum 25(OH)D, ß-hCG and PAPP-A levels were measured in the first trimester of otherwise healthy Spanish pregnant women (n=488). Rho Spearman coefficients were calculated to determine correlations between analytes.
Results. Median serum 25(OH)D levels for the entire sample was 27.4 ng/mL (interquartile range=12.1). 25(OH)D levels were insufficient (20 to 29.99 ng/mL) and deficient (< 20 ng/mL) in 40.6% and 23.2% respectively, in relation to ethnics, body mass index values, tobacco use and season/gestational age at blood sampling. β-hCG and PAPP-A levels significantly correlated (r2= 0.47) yet neither of them with 25(OH)D levels. Despite this, the three analytes significantly correlated with gestational age at sampling. Conclusion. First trimester 25(OH)D, β-hCG and PAPP-A levels increase with gestational age however placental peptides do not correlate with vitamin D levels, suggesting a non placental 25(OH)D production. More research is required in this regard.
Keywords: Vitamin D, 25-hydroxyvitamin D, ß-hCG, PAPP-A, first trimester pregnancy